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Host-aware synthetic biology

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Title: Host-aware synthetic biology
Authors: Boo, A
Ellis, T
Stan, G
Item Type: Journal Article
Abstract: Unnatural gene expression imposes a load on engineered microorganisms thatdecreases their growth and subsequent production yields, a phenomenon knownasburden. In the last decade, the field of synthetic biology has made progress onthe development of biomolecular feedback control systems and other approachesthat can improve the growth of engineered cells, as well as the genetic stability,portability and robust performance of cell-hosted synthetic constructs. In thisreview, we highlight recent work focused on the development of host-aware syn-thetic biology.
Issue Date: 1-Apr-2019
Date of Acceptance: 6-Mar-2019
URI: http://hdl.handle.net/10044/1/68705
DOI: https://dx.doi.org/10.1016/j.coisb.2019.03.001
ISSN: 2452-3100
Publisher: Elsevier
Start Page: 66
End Page: 72
Journal / Book Title: Current Opinion in Systems Biology
Volume: 14
Copyright Statement: Crown Copyright © 2019 Published by Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/M002187/1
EP/M002306/1
Publication Status: Published
Embargo Date: 2020-03-14
Online Publication Date: 2019-03-14
Appears in Collections:Faculty of Engineering
Bioengineering



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