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Treatment outcomes in global systematic review and patient meta-analysis of children with extensively drug-resistant tuberculosis

Title: Treatment outcomes in global systematic review and patient meta-analysis of children with extensively drug-resistant tuberculosis
Authors: Osman, M
Harausz, EP
Garcia-Prats, AJ
Schaaf, HS
Moore, BK
Hicks, RM
Achar, J
Amanullah, F
Barry, P
Becerra, M
Chiotan, DI
Drobac, PC
Flood, J
Furin, J
Gegia, M
Isaakidis, P
Mariandyshev, A
Ozere, I
Shah, NS
Skrahina, A
Yablokova, E
Seddon, JA
Hesseling, AC
Item Type: Journal Article
Abstract: Extensively drug-resistant tuberculosis (XDR TB) has ex-tremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifesta-tions, treatment, and outcomes for 37 children (<15 years of age) with bacteriologically confirmed XDR TB in 11 coun-tries. These patients were managed during 1999–2013. For the 37 children, median age was 11 years, 32 (87%) had pulmonary TB, and 29 had a recorded HIV status; 7 (24%) were infected with HIV. Median treatment duration was 7.0 months for the intensive phase and 12.2 months for the continuation phase. Thirty (81%) children had favor-able treatment outcomes. Four (11%) died, 1 (3%) failed treatment, and 2 (5%) did not complete treatment. We found a high proportion of favorable treatment outcomes among children, with mortality rates markedly lower than for adults. Regimens and duration of treatment varied considerably. Evaluation of new regimens in children is required.
Issue Date: 1-Mar-2019
Date of Acceptance: 1-Mar-2019
URI: http://hdl.handle.net/10044/1/68648
DOI: https://dx.doi.org/10.3201/eid2503.180852
ISSN: 1080-6040
Publisher: U.S. National Center for Infectious Diseases
Start Page: 441
End Page: 450
Journal / Book Title: Emerging Infectious Diseases
Volume: 25
Issue: 3
Copyright Statement: Emerging Infectious Diseases is an open access journal in the public domain. All content is freely available without charge to the user or his/her institution. In accordance with the Budapest Open Access Initiative definition of Open Access, users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. Because the journal is in the public domain, its usage policy also conforms to conditions set for by Creative Commons (https://creativecommons.org/licenses/by/4.0/)
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
MULTIDRUG-RESISTANT
MYCOBACTERIUM-TUBERCULOSIS
SOUTH-AFRICA
HEARING-LOSS
DISEASE
TB
ADOLESCENTS
COLLECTION
MORTALITY
DIAGNOSIS
MDR TB
XDR TB
antimicrobial resistance
bacteria
children
extensively drug-resistant tuberculosis
global systematic review
meta-analysis
mortality
multidrug-resistant TB
outcomes
respiratory infections
treatment outcomes
tuberculosis
tuberculosis and other mycobacteria
Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR TB
1108 Medical Microbiology
1117 Public Health And Health Services
1103 Clinical Sciences
Microbiology
Publication Status: Published
Online Publication Date: 2019-03-01
Appears in Collections:Department of Medicine



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