Maternal Serum B Cell activating factor in hypertensive and normotensive pregnancies

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Title: Maternal Serum B Cell activating factor in hypertensive and normotensive pregnancies
Authors: Tay, J
Costanzi, A
Basello, K
Piuri, G
Ferrazzi, E
Speciani, AF
Lees, CC
Item Type: Journal Article
Abstract: Objectives The objective of this study was the analysis of B-Cell Activating Factor (BAFF) levels in pregnancies affected by PE, and in pregnancies affected by fetal growth restriction without Hypertensive disorders and its possible correlation with pulse wave velocity and cardiac output. Study design Prospective study of 69 women at 24–40 weeks gestation. Haemodynamic function was assessed in those with Pre-eclampsia (PE, n = 19), fetal growth restriction (FGR, n = 10) and healthy pregnancies (n = 40). Maternal venous BAFF levels at recruitment were measured using ELISA. We analysed the relationship between BAFF and cardiac output (CO), and BAFF and PWV (pulse wave velocity); the gold standard for assessing arterial stiffness. PWV was measured with an oscillometric device and CO using inert gas rebreathing technique. PWV and CO were converted to gestation adjusted indices (z scores). Main outcome measures The association between BAFF levels in PE and FGR, and the relationship of BAFF with PWV and CO. Results BAFF was higher in PE (p = 0.03) but not in FGR (p = 0.83) when compared to healthy pregnancies. There was a positive correlation between BAFF levels and z score PWV (r = 0.25, p = 0.04), but not CO (r = −0.01, p = 0.91). BAFF levels did not change with gestational age. (r = 0.012, p = 0.925). Conclusions These findings provide evidence of a possible contribution of BAFF to both maternal inflammation and arterial dysfunction associated with PE. Though no relationship was found with another disorder of placentation: normotensive FGR, this condition is not thought to be associated with maternal inflammation.
Issue Date: 1-Jul-2018
Date of Acceptance: 2-May-2018
URI: http://hdl.handle.net/10044/1/68182
DOI: https://doi.org/10.1016/j.preghy.2018.05.001
ISSN: 2210-7789
Publisher: Elsevier
Start Page: 58
End Page: 61
Journal / Book Title: Pregnancy Hypertension
Volume: 13
Copyright Statement: © 2018 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Imperial College Healthcare Charity
Funder's Grant Number: 151612
Keywords: Science & Technology
Life Sciences & Biomedicine
Obstetrics & Gynecology
Peripheral Vascular Disease
Cardiovascular System & Cardiology
Pre-eclampsia
Fetal growth restriction
BAFF
Pulse wave velocity
Arterial function
FETAL-GROWTH RESTRICTION
PREECLAMPSIA
ARTERIAL
APRIL
DISORDERS
VELOCITY
Adult
B-Cell Activating Factor
Cardiac Output
Female
Fetal Growth Retardation
Gestational Age
Humans
Pre-Eclampsia
Pregnancy
Prenatal Diagnosis
Prospective Studies
Pulse Wave Analysis
Regional Blood Flow
Publication Status: Published
Online Publication Date: 2018-05-03
Appears in Collections:Division of Surgery
Faculty of Medicine



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