Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

Title: Do people living with HIV experience greater age advancement than their HIV-negative counterparts?
Authors: De Francesco, D
Wit, FW
Burkle, A
Oehlke, S
Kootstra, NA
Winston, A
Franceschi, C
Garagnani, P
Pirazzini, C
Libert, C
Grune, T
Salvioli, S
Fuchs, D
Zetterberg, H
Weber, D
Grune, T
Jansen, EHJM
De Francesco, D
Sindlinger, T
Oehlke, S
Weber, D
Jansen, EHJM
Sabin, CA
Reiss, P
Reiss, P
Winston, A
Wit, FW
Prins, M
Van der Loeff, MFS
Schouten, J
Schmand, B
Geurtsen, GJ
Sharp, DJ
Caan, MWA
Majoie, C
Villaudy, J
Berkhout, B
Kootstra, NA
Gisslen, M
Pasternak, A
Sabin, CA
Guaraldi, G
Burkle, A
Libert, C
Franceschi, C
Kalsbeek, A
Fliers, E
Hoeijmakers, J
Pothof, J
Van der Valk, M
Bisschop, PH
Portegies, P
Zaheri, S
Burger, D
Cole, JH
Biirkle, A
Zikkenheiner, W
Janssen, FR
Underwood, J
Kooij, KW
Van Zoest, RA
Doyle, N
Van der Loeff, MS
Schmand, BA
Verheij, E
Verboeket, SO
Elsenga, BC
Hillebregt, MMJ
Ruijs, YMC
Benschop, DP
Tembo, L
McDonald, L
Stott, M
Legg, K
Lovell, A
Erlwein, O
Kingsley, C
Norsworthy, P
Mullaney, S
Kruijer, T
Del Grande, L
Olthof, V
Visser, GR
May, L
Verbraak, F
Demirkaya, N
Visser, I
Majoie, CBLM
Su, T
Leech, R
Huguet, J
Frankin, E
Van der Kuyl, A
Weijer, K
Siteur-Van Rijnstra, E
Harskamp-Holwerda, AM
Maurer, I
Ruiz, MMM
Girigorie, AF
Boeser-Nunnink, B
Kals-Beek, A
Bisschop, PHLT
De Graaff-Teulen, M
Dewaele, S
Garagnani, P
Pirazzini, C
Capri, M
Dall'Olio, F
Chiricolo, M
Item Type: Journal Article
Abstract: Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH) may show signs of premature/accentuated aging. We compared established biomarkers of aging in PLWH, appropriately chosen HIV-negative individuals, and blood donors, and explored factors associated with biological age advancement. Design: Cross-sectional analysis of 134 PLWH on suppressive antiretroviral therapy, 79 lifestyle-comparable HIV-negative controls aged 45 years or older from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors. Methods: Biological age was estimated using a validated algorithm based on 10 biomarkers. Associations between ‘age advancement’ (biological minus chronological age) and HIV status/parameters, lifestyle, cytomegalovirus (CMV), hepatitis B (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression. Results: The average (95% CI) age advancement was greater in both HIV-positive [13.2 (11.6–14.9) years] and HIV-negative [5.5 (3.8–7.2) years] COBRA participants compared with blood donors [7.0 (4.1 to 9.9) years, both P’s< 0.001)], but also in HIV-positive compared with HIV-negative participants (P < 0.001). Chronic HBV, higher anti-CMV IgG titer and CD8þ T-cell count were each associated with increased age advancement, independently of HIV-status/group. Among HIV-positive participants, age advancement was increased by 3.5 (0.1–6.8) years among those with nadir CD4þ T-cell count less than 200 cells/ml and by 0.1 (0.06–0.2) years for each additional month of exposure to saquinavir.
Issue Date: 1-Feb-2019
Date of Acceptance: 28-Jun-2018
URI: http://hdl.handle.net/10044/1/68177
DOI: https://doi.org/10.1097/QAD.0000000000002063
ISSN: 0269-9370
Publisher: Lippincott, Williams & Wilkins
Start Page: 259
End Page: 268
Journal / Book Title: AIDS
Volume: 33
Issue: 2
Copyright Statement: © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND - https://creativecommons.org/licenses/by-nc-nd/4.0/), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Virology
accelerated aging
aging
biological age
biomarkers of aging
HIV
premature aging
IMMUNOGLOBULIN-G ANTIBODY
INFECTED INDIVIDUALS
PROTEASE INHIBITORS
SOUTH-AFRICA
RISK-FACTORS
BIOMARKERS
DISEASE
CYTOMEGALOVIRUS
COMORBIDITIES
POPULATION
the Co-morBidity in Relation to AIDS (COBRA) Collaboration
06 Biological Sciences
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status: Published
Online Publication Date: 2019-02-01
Appears in Collections:Department of Medicine



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