Gynecological cancers translational, research implementation, and harmonization: Gynecologic Cancer InterGroup consensus and still open questions

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Title: Gynecological cancers translational, research implementation, and harmonization: Gynecologic Cancer InterGroup consensus and still open questions
Authors: Bagnoli, M
Shi, TY
Gourley, C
Speiser, P
Reuss, A
Nijman, HW
Creutzberg, CL
Scholl, S
Negrouk, A
Brady, MF
Hasegawa, K
Oda, K
McNeish, IA
Kohn, EC
Oza, AM
MacKay, H
Millan, D
Bennett, K
Scott, C
Mezzanzanica, D
Item Type: Journal Article
Abstract: In the era of personalized medicine, the introduction of translational studies in clinical trials has substantially increased their costs, but provides the possibility of improving the productivity of trials with a better selection of recruited patients. With the overall goal of creating a roadmap to improve translational design for future gynecological cancer trials and of defining translational goals, a main discussion was held during a brainstorming day of the Gynecologic Cancer InterGroup (GCIG) Translational Research Committee and overall conclusions are here reported. A particular emphasis was dedicated to the new frontier of the immunoprofiling of gynecological cancers. The discussion pointed out that to maximize patients’ benefit, translational studies should be integral to clinical trial design with standardization and optimization of procedures including a harmonization program of Standard Operating Procedures. Pathology-reviewed sample collection should be mandatory and ensured by dedicated funding. Biomarker validation and development should be made public and transparent to ensure rapid progresses with positive outcomes for patients. Guidelines/templates for patients’ informed consent are needed. Importantly for the public, recognized goals are to increase the involvement of advocates and to improve the reporting of translational data in a forum accessible to patients.
Issue Date: 26-Feb-2019
Date of Acceptance: 26-Feb-2019
URI: http://hdl.handle.net/10044/1/68106
DOI: https:/d/x.doi.org/10.3390/cells8030200
ISSN: 2073-4409
Publisher: MDPI AG
Journal / Book Title: Cells
Volume: 8
Issue: 3
Copyright Statement: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Keywords: biomarkers definition
gynecological cancers
precision medicine
samples collection
translational studies design
Publication Status: Published
Article Number: ARTN 200
Online Publication Date: 2019-03-01
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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