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The design and in vivo testing of a locally stiffness-matched porous scaffold

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Title: The design and in vivo testing of a locally stiffness-matched porous scaffold
Authors: Ghouse, S
Reznikov, N
Boughton, O
Babu, S
Ng, KCG
Blunn, G
Cobb, J
Stevens, M
Jeffers, J
Item Type: Journal Article
Abstract: An increasing volume of work supports utilising the mechanobiology of bone for bone ingrowth into a porous scaffold. However, typically during in vivo testing of implants, the mechanical properties of the bone being replaced are not quantified. Consequently there remains inconsistencies in the literature regarding ‘optimum’ pore size and porosity for bone ingrowth. It is also difficult to compare ingrowth results between studies and to translate in vivo animal testing to human subjects without understanding the mechanical environment. This study presents a clinically applicable approach to determining local bone mechanical properties and design of a scaffold with similar properties. The performance of the scaffold was investigated in vivo in an ovine model. The density, modulus and strength of trabecular bone from the medial femoral condyle from ovine bones was characterised and power-law relationships were established. A porous titanium scaffold, intended to maintain bone mechanical homeostasis, was additively manufactured and implanted into the medial femoral condyle of 6 ewes. The stiffness of the scaffold varied throughout the heterogeneous structure and matched the stiffness variation of bone at the surgical site. Bone ingrowth into the scaffold was 10.73 ± 2.97% after 6 weeks. Fine woven bone, in the interior of the scaffold, and intense formations of more developed woven bone overlaid with lamellar bone at the implant periphery were observed. The workflow presented will allow future in vivo testing to test specific bone strains on bone ingrowth in response to a scaffold and allow for better translation from in vivo testing to commercial implants.
Issue Date: 1-Jun-2019
Date of Acceptance: 22-Feb-2019
URI: http://hdl.handle.net/10044/1/68012
DOI: https://dx.doi.org/10.1016/j.apmt.2019.02.017
ISSN: 2352-9407
Publisher: Elsevier
Start Page: 377
End Page: 388
Journal / Book Title: Applied Materials Today
Volume: 15
Copyright Statement: © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Sponsor/Funder: Wellcome Trust
Wellcome Trust
Wellcome Trust
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Medical Research Council (MRC)
Funder's Grant Number: 088844/Z/09/Z
097816/Z/11/B
098411/Z/12/Z
EP/K027549/1
RC0000658 / RG.MECH.115148
EP/R042721/1
MR/R015651/1
Publication Status: Published
Online Publication Date: 2019-03-14
Appears in Collections:Faculty of Engineering
Mechanical Engineering
Materials
Division of Surgery
Faculty of Medicine
Faculty of Natural Sciences



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