Disseminated CMV infection and HLH in a patient with well-controlled HIV and ulcerative colitis

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Title: Disseminated CMV infection and HLH in a patient with well-controlled HIV and ulcerative colitis
Authors: Cockbain, BC
Mora Peris, B
Abbara, A
So, CW
Cooke, G
Item Type: Journal Article
Abstract: We present a case of haemophagocytic lymphohistiocytosis (HLH) in the context of disseminated cytomegalovirus (CMV) viraemia in a 50-year-old man with well-controlled HIV infection and ulcerative colitis (UC), for which he was receiving azathioprine. Peak CMV viral load was 371 000 copies/ml with evidence of end-organ CMV in the lungs and colon. A bone marrow biopsy showed evidence of haemophagocytosis of platelets, neutrophils and erythrocytes. The azathioprine was stopped, and he received intravenous ganciclovir and corticosteroids with suppression of the CMV viral load and resolution of the HLH.
Issue Date: 11-Feb-2019
Date of Acceptance: 7-Jan-2019
URI: http://hdl.handle.net/10044/1/67994
DOI: https://dx.doi.org/10.1136/bcr-2018-227916
ISSN: 1757-790X
Publisher: BMJ Publishing Group
Journal / Book Title: BMJ Case Reports
Volume: 12
Issue: 2
Copyright Statement: © BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Keywords: HIV / AIDS
immunology
infectious diseases
inflammatory bowel disease
pathology
Publication Status: Published
Conference Place: England
Online Publication Date: 2019-02-11
Appears in Collections:Department of Medicine
Faculty of Medicine



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