Xenogeneic regulation of the bacterial transcription machinery

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Title: Xenogeneic regulation of the bacterial transcription machinery
Authors: Tabib-Salazar, A
Mulvenna, N
Severinov, K
Matthews, SJ
Wigneshweraraj, S
Item Type: Journal Article
Abstract: The parasitic life cycle of viruses involves the obligatory subversion of the host's macromolecular processes for efficient viral progeny production. Viruses that infect bacteria, bacteriophages (phages), are no exception and have evolved sophisticated ways to control essential biosynthetic machineries of their bacterial prey to benefit phage development. The xenogeneic regulation of bacterial cell function is a poorly understood area of bacteriology. The activity of the bacterial transcription machinery, the RNA polymerase (RNAP), is often regulated by a variety of mechanisms involving small phage-encoded proteins. In this review, we provide a brief overview of known phage proteins that interact with the bacterial RNAP and compare how two prototypical phages of Escherichia coli, T4 and T7, use small proteins to 'puppeteer' the bacterial RNAP to ensure a successful infection.
Issue Date: 15-Feb-2019
Date of Acceptance: 6-Feb-2019
URI: http://hdl.handle.net/10044/1/67834
DOI: https://doi.org/10.1016/j.jmb.2019.02.008
ISSN: 0022-2836
Publisher: Elsevier
Journal / Book Title: Journal of Molecular Biology
Copyright Statement: © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Sponsor/Funder: Wellcome Trust
Wellcome Trust
Funder's Grant Number: 100958/Z/13/Z
Keywords: Escherichia coli
RNA polymerase
T4 phage
T7 phage
0601 Biochemistry And Cell Biology
Biochemistry & Molecular Biology
Publication Status: Published online
Conference Place: England
Online Publication Date: 2019-02-15
Appears in Collections:Department of Medicine
Faculty of Medicine
Faculty of Natural Sciences

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