Estimating HIV incidence from surveillance data indicates a second wave of infections in Brazil

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Title: Estimating HIV incidence from surveillance data indicates a second wave of infections in Brazil
Authors: Mangal, TD
Pascom, ARP
Vesga, JF
Meireles, MV
Benzaken, AS
Hallett, TB
Item Type: Journal Article
Abstract: Emerging evidence suggests that HIV incidence rates in Brazil, particularly among men, may be rising. Here we use Brazil’s integrated health systems data to develop a mathematical model, reproducing the complex surveillance systems and providing estimates of HIV incidence, number of people living with HIV (PLHIV), reporting rates and ART initiation rates. An age-structured deterministic model with a flexible spline was used to describe the natural history of HIV along with reporting and treatment rates. Individual-level surveillance data for 1,077,295 cases (HIV/AIDS diagnoses, ART dispensations, CD4 counts and HIV/AIDS-related deaths) were used to calibrate the model using Bayesian inference. The results showed a second wave of infections occurring after 2001 and 56,000 (95% Credible Interval 43,000–71,000) new infections in 2015, 37,000 (95% CrI 28,000–54,000) infections in men and 16,000 (95% CrI 10,000–23,000) in women. The estimated number of PLHIV by end-2015 was 838,000 (95% CrI 675,000–1,083,000), with 80% (95% CrI 62–98%) of those individuals reported to the Ministry of Health. Women were more likely to be diagnosed and reported than men; 86.8% of infected women had been reported compared with 75.7% of men. Likewise, ART initiation rates for women were higher than those for men. The second wave contradicts previous estimates of HIV incidence trends in Brazil and there were persistent differences in the rates of accessing care between men and women. Nevertheless, the Brazilian HIV program has achieved high rates of detection and treatment, making considerable progress over the past ten years.
Issue Date: 1-Jun-2019
Date of Acceptance: 4-Feb-2019
URI: http://hdl.handle.net/10044/1/67753
DOI: https://doi.org/10.1016/j.epidem.2019.02.002
ISSN: 1755-4365
Publisher: Elsevier BV
Start Page: 77
End Page: 85
Journal / Book Title: Epidemics
Volume: 27
Copyright Statement: © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Sponsor/Funder: Bill & Melinda Gates Foundation
Medical Research Council (MRC)
Funder's Grant Number: OPP1084364
MR/R015600/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
HIV/AIDS
Incidence estimation
Brazil
Deterministic model
Prevalence
HIV care cascade
AIDS EPIDEMIC
PREVALENCE
SURVIVAL
DEATHS
TRENDS
MODEL
Brazil
Deterministic model
HIV care cascade
HIV/AIDS
Incidence estimation
Prevalence
1103 Clinical Sciences
1117 Public Health and Health Services
Publication Status: Published
Open Access location: https://www.sciencedirect.com/science/article/pii/S1755436518301178?via%3Dihub
Online Publication Date: 2019-02-07
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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