Autoantibodies in cryptogenic fibrosing alveolitis

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Title: Autoantibodies in cryptogenic fibrosing alveolitis
Authors: Singh, S
Du Bois, R
Item Type: Journal Article
Abstract: The pathogenesis of cryptogenic fibrosing alveolitis (CFA) involves injury, an immune/inflammatory response and fibrosis. The cause of the injury is unknown, but the identification of serum autoantibodies makes an autoimmune aetiology attractive. The core study on which this commentary is based used novel cloning and serum screening technologies in order to identify new public and private autoantibodies in sera from 12 patients with CFA. Largely negative conclusions were drawn from that study. However, we suggest that the prevalence of autoantibodies may have been underestimated, that the study was timely and that this approach is worth pursuing further.
Issue Date: 21-Feb-2001
Date of Acceptance: 2-Feb-2001
URI: http://hdl.handle.net/10044/1/67486
DOI: https://dx.doi.org/10.1186/rr38
ISSN: 1465-9921
Publisher: BioMed Central
Start Page: 61
End Page: 63
Journal / Book Title: Respiratory Research
Volume: 2
Issue: 1
Copyright Statement: © 2001 BioMed Central Ltd.
Keywords: Science & Technology
Life Sciences & Biomedicine
Respiratory System
autoantibodies
cryptogenic fibrosing alveolitis
expression libraries
idiopathic pulmonary fibrosis
pathogenesis
IDIOPATHIC PULMONARY FIBROSIS
EPSTEIN-BARR-VIRUS
CLINICAL RELEVANCE
IMMUNE-COMPLEXES
ASSOCIATION
Autoantibodies
Humans
Pulmonary Fibrosis
Th1 Cells
Th2 Cells
1102 Cardiovascular Medicine And Haematology
1103 Clinical Sciences
Publication Status: Published
Article Number: 61
Online Publication Date: 2001-02-21
Appears in Collections:Division of Surgery
National Heart and Lung Institute
Faculty of Medicine



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