General and abdominal adiposity and the risk of parkinson's disease.A prospective chort study

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Title: General and abdominal adiposity and the risk of parkinson's disease.A prospective chort study
Authors: Riso, L
Kaaks, R
Kühn, T
Sookthai, D
Forsgren, L
Trupp, M
Trichopoulou, A
La Vecchia, C
Karakatsani, A
Gavrila, D
Ferrari, P
Freisling, H
Petersson, J
Lewan, S
Vermeulen, RC
Panico, S
Masala, G
Ardanaz, E
Krogh, V
Perneczky, RG
Middleton, LT
Mokoroa, O
Sacerdote, C
Sieri, S
Hayat, SA
Brayne, C
Riboli, E
Vineis, P
Gallo, V
Katzke, VA
Item Type: Journal Article
Abstract: Introduction Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD. Methods In 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Cox proportional hazards regression was used to calculate hazard ratios (HR) with 95% confidence intervals (CI). We modelled anthropometric variables as continuous and categorical exposures and performed subgroup analyses by potential effect modifiers including sex and smoking. Results We found no association between BMI, WC and incident PD, neither among men nor among women. Among never and former smokers, BMI and waist circumference were also not associated with PD risk. For male smokers, however, we observed a statistically significant inverse association between BMI and PD risk (HR 0.51, 95%CI: 0.30, 0.84) and the opposite for women, i.e. a significant direct association of BMI (HR 1.79, 95%CI: 1.04, 3.08) and waist circumference (HR 1.64, 95%CI: 1.03, 2.61) with risk of PD. Conclusion Our data revealed no association between excess weight and PD risk but a possible interaction between anthropometry, sex and smoking.
Issue Date: 8-Feb-2019
Date of Acceptance: 8-Feb-2019
URI: http://hdl.handle.net/10044/1/67474
DOI: https://dx.doi.org/10.1016/j.parkreldis.2019.01.019
ISSN: 1353-8020
Publisher: Elsevier
Journal / Book Title: Parkinsonism and Related Disorders
Copyright Statement: © 2019 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Commission of the European Communities
Michael J Fox Foundation
Funder's Grant Number: SP23-CT-2005-006438
MJFF Research grant 2010 prog
Keywords: BMI
Cohort
EPIC
Overweight
Parkinson
Smoking
1103 Clinical Sciences
1702 Cognitive Science
Neurology & Neurosurgery
Publication Status: Published online
Embargo Date: 2020-02-08
Online Publication Date: 2019-02-08
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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