Unmet medical needs in metastatic lung and digestive neuroendocrine neoplasms

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Title: Unmet medical needs in metastatic lung and digestive neuroendocrine neoplasms
Authors: Capdevila, J
Bodei, L
Davies, P
Gorbounova, V
Jensen, RT
Knigge, UP
Krejs, GJ
Krenning, E
O'Connor, JM
Peeters, M
Rindi, G
Salazar, R
Vullierme, M-P
Pavel, ME
Arnold, R
Bartsch, D
Baudin, E
Bodei, L
Borbath, I
Capdevila, J
Caplin, M
Chen, J
Costa, F
Couvelard, A
Cwikla, JB
Davies, P
De Herder, WW
Falconi, M
Falkerby, J
Fazio, N
Ferone, D
Frilling, A
Garcia-Carbonero, R
Glasberg, S
Gorbunova, V
Grossman, A
Hoersch, D
Jensen, RT
Kaltsas, G
Kloeppel, G
Knigge, UP
Kos-Kudla, B
Krejs, GJ
Krenning, E
Kulke, M
Lamberts, SWJ
Van Dijkum, NE
O'Connor, JM
O'Toole, D
Pape, UF
Partelli, S
Pavel, ME
Peeters, M
Ramage, J
Reed, NSB
Rindi, G
Rinke, A
Ruszniewski, P
Sorbye, H
Sundin, A
Scoazec, JY
Taal, BG
Tiensuu, JE
Toumpanakis, C
Valle, J
Vullierme, MP
Welin, S
Wiedenmann, B
Item Type: Journal Article
Abstract: Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered, and decisions in our daily clinical practice should be made with limited evidence. In the 2016 meeting of the advisory board of the European Neuroendocrine Tumor Society (ENETS), the main unmet medical needs in the metastatic NENs setting were deeply discussed, and several proposals to try to solve them are presented in this article, including biomarkers, imaging, and therapy.
Issue Date: 1-Jan-2019
Date of Acceptance: 27-Aug-2018
URI: http://hdl.handle.net/10044/1/67386
DOI: https://dx.doi.org/10.1159/000493319
ISSN: 0028-3835
Publisher: Karger Publishers
Start Page: 18
End Page: 25
Journal / Book Title: Neuroendocrinology
Volume: 108
Issue: 1
Copyright Statement: © 2018 S. Karger AG, Basel.
Sponsor/Funder: Dr. Heinz-Horst Deichmann Stiftung
Funder's Grant Number: n/a
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Neurosciences
Neurosciences & Neurology
Unmet medical needs
Neuroendocrine neoplasms
Metastasis
Biomarkers
Imaging
Therapy
TUMORS
SUNITINIB
LANREOTIDE
EVEROLIMUS
SURVIVAL
ENETS 2016 Munich Advisory Board Participants
ENETS 2016 Munich Advisory Board Participants
1103 Clinical Sciences
1109 Neurosciences
Publication Status: Published
Online Publication Date: 2018-08-28
Appears in Collections:Division of Surgery
Faculty of Medicine



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