Dairy product intake and risk of type 2 diabetes in EPIC-InterAct: a mendelian randomization study

Title: Dairy product intake and risk of type 2 diabetes in EPIC-InterAct: a mendelian randomization study
Authors: Vissers, LET
Sluijs, I
Van der Schouw, YT
Forouhi, NG
Imamura, F
Burgess, S
Barricarte, A
Boeing, H
Bonet, C
Chirlaque, M-D
Fagherazzi, G
Franks, PW
Freisling, H
Gunter, MJ
Quirós, JR
Ibsen, DB
Kaaks, R
Key, T
Khaw, KT
Kühn, T
Mokoroa, O
Nilsson, PM
Overvad, K
Pala, V
Palli, D
Panico, S
Sacerdote, C
Spijkerman, AMW
Tjonneland, A
Tumino, R
Rodríguez-Barranco, M
Rolandsson, O
Riboli, E
Sharp, SJ
Langenberg, C
Wareham, NJ
Item Type: Journal Article
Abstract: OBJECTIVE To estimate the causal association between intake of dairy products and incident type 2 diabetes. RESEARCH DESIGN AND METHODS The analysis included 21,820 European individuals (9,686 diabetes cases) of the EPIC-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a SNP for lactase persistence (LP) which enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression. RESULTS Each additional LP allele was associated with a higher intake of milk (β 17.1 g/day, 95% CI 10.6–23.6) and milk beverages (β 2.8 g/day, 95% CI 1.0–4.5) but not with intake of other dairy products. Other dietary intakes associated with rs4988235 included fruits (β −7.0 g/day, 95% CI −12.4 to −1.7 per additional LP allele), nonalcoholic beverages (β −18.0 g/day, 95% CI −34.4 to −1.6), and wine (β −4.8 g/day, 95% CI −9.1 to −0.6). In instrumental variable analysis, LP-associated milk intake was not associated with diabetes (hazard ratio 0.99per 15 g/day, 95% CI 0.93–1.05). CONCLUSIONS rs4988235 was associated with milk intake but not with intake of other dairy products. This MR study does not suggest that milk intake is associated with diabetes, which is consistent with previous observational and genetic associations. LP may be associated with intake of other foods as well, but owing to the modest associations we consider it unlikely that this has caused the observed null result.
Issue Date: 1-Mar-2019
Date of Acceptance: 16-Jan-2019
ISSN: 0149-5992
Publisher: American Diabetes Association
Journal / Book Title: Diabetes Care
Volume: 42
Issue: 3
Copyright Statement: © 2019 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: SP23-CT-2005-006438
Keywords: 11 Medical And Health Sciences
Endocrinology & Metabolism
Publication Status: Published
Online Publication Date: 2019-02-06
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care

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