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The influence of constraints on the efficient allocation of resources for HIV prevention: a modelling study

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Title: The influence of constraints on the efficient allocation of resources for HIV prevention: a modelling study
Authors: Stopard, I
Hallett, TB
Hauck, K
McGillen, J
Item Type: Journal Article
Abstract: Objective: To investigate how ‘real-world’ constraints on the allocative and technical efficiency of HIV prevention programmes affect resource allocation and the number of infections averted. Design: Epidemiological modelling and economic analyses in Benin, South Africa and Tanzania. Methods: We simulated different HIV prevention programmes, and first determined the most efficient allocation of resources, in which the HIV prevention budget is shared between specific interventions, risk-groups and provinces to maximise the number of infections averted. We then identified the efficient allocation of resources and achievable impact given constraints to allocative efficiency: earmarking (provinces with budgets fund PrEP for low-risk women first), meeting treatment targets (provinces with budgets fund UTT first) and minimizing changes in the geographical distribution of funds. We modelled technical inefficiencies as a reduction in the coverage of PrEP or UTT, which were factored into the resource allocation process or took effect following the allocation. Each scenario was investigated over a range of budgets, such that the impact reaches its maximum. Results: The ‘earmarking’, ‘meeting targets’ and ‘minimizing change’ constraints reduce the potential impact of HIV prevention programmes, but at the higher budgets these constraints have little to no effect (approximately 35 billion US$ in Tanzania). Over-estimating technical efficiencies results in a loss of impact compared to what would be possible if technical efficiencies were known accurately. Conclusions: Failing to account for constraints on allocative and technical efficiency can result in the overestimation of the health gains possible, and for technical inefficiencies the allocation of an inefficient strategy.
Issue Date: 9-Feb-2019
Date of Acceptance: 10-Jan-2019
URI: http://hdl.handle.net/10044/1/67101
DOI: https://dx.doi.org/10.1097/QAD.0000000000002158
ISSN: 0269-9370
Publisher: Lippincott, Williams & Wilkins
Journal / Book Title: AIDS
Copyright Statement: © 2019 Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0, (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
Sponsor/Funder: Bill & Melinda Gates Foundation
National Institute for Health Research
Pepfar, NIAID, NIMH, NIDA, BMGF
Medical Research Council (MRC)
Medical Research Council
Funder's Grant Number: OPP1084364
HPRU-2012-10080
MR/R015600/1
MR/K010174/1B
Keywords: 06 Biological Sciences
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Virology
Publication Status: Published online
Online Publication Date: 2019-02-09
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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