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Hyaluronic acid-based activatable nanomaterials for stimuli-responsive imaging and therapeutics: beyond CD44-mediated drug delivery

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Title: Hyaluronic acid-based activatable nanomaterials for stimuli-responsive imaging and therapeutics: beyond CD44-mediated drug delivery
Authors: Choi, KY
Han, HS
Lee, ES
Shin, JM
Almquist, B
Lee, DS
Park, JH
Item Type: Journal Article
Abstract: There is a rapidly increasing interest in developing stimuli-responsive nanomaterials for treating a variety of diseases. By enabling the activation of function locally at the sites of interest, it is possible to increase therapeutic efficacy significantly while simultaneously reducing adverse side effects. While there are many sophisticated nanomaterials available, they are many times highly complex and not easily transferrable to industrial scales and clinical settings. However, hyaluronic acid-based nanomaterials offer a compelling strategy for reducing the complexity of nanomaterials while retaining several desirable benefits such as active targeting and stimuli-responsive degradation. In this report, we cover the basic properties of hyaluronic acid, its binding partners, and natural routes for degradation by hyaluronidases—hyaluronic acid-degrading enzymes—and oxidative stresses. We then cover recent advances in designing hyaluronic acid-based, actively targeted, hyaluronidase- or reactive oxygen species-responsive nanomaterials for both diagnostic imaging and therapeutic delivery that go beyond merely the classical targeting of CD44.
Issue Date: 18-Feb-2019
Date of Acceptance: 28-Dec-2018
URI: http://hdl.handle.net/10044/1/66918
DOI: https://dx.doi.org/10.1002/adma.201803549
ISSN: 0935-9648
Publisher: Wiley
Journal / Book Title: Advanced Materials
Copyright Statement: © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the pre-peer reviewed version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201803549
Keywords: 02 Physical Sciences
03 Chemical Sciences
09 Engineering
Nanoscience & Nanotechnology
Publication Status: Published online
Embargo Date: 2020-02-18
Article Number: 1803549
Online Publication Date: 2019-02-18
Appears in Collections:Faculty of Engineering
Bioengineering



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