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Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides

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Title: Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides
Authors: Tascini, AS
Noro, MG
Seddon, JM
Chen, R
Bresme, F
Item Type: Journal Article
Abstract: The skin surface, our first barrier against the external environment, is covered by the sebum oil, a lipid film composed of sebaceous and epidermal lipids, which is important in the regulation of the hydration level of our skin. Here, we investigate the pathways leading to the transfer of epidermal lipids from the skin lipid bilayer to the sebum. We show that the sebum triglycerides, a major component of sebum, interact strongly with the epidermal lipids and extract them from the bilayer. Using microsecond time scale molecular dynamics simulations, we identify and quantify the free energy associated with the skin lipid extraction process.
Issue Date: 21-Jan-2019
Date of Acceptance: 9-Dec-2018
URI: http://hdl.handle.net/10044/1/66704
DOI: https://dx.doi.org/10.1039/c8cp05706k
ISSN: 1463-9076
Publisher: Royal Society of Chemistry
Start Page: 1471
End Page: 1477
Journal / Book Title: Physical Chemistry Chemical Physics
Volume: 21
Issue: 3
Copyright Statement: This journal is © the Owner Societies 2019.
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 608184
Keywords: Science & Technology
Physical Sciences
Chemistry, Physical
Physics, Atomic, Molecular & Chemical
Chemistry
Physics
CHOLESTEROL FLIP-FLOP
MOLECULAR-DYNAMICS
CERAMIDE BILAYERS
DRUG-DELIVERY
FATTY-ACIDS
MODEL
SIMULATION
BARRIER
WATER
NANOPARTICLES
Ceramides
Cholesterol
Epidermis
Fatty Acids
Lipid Bilayers
Molecular Dynamics Simulation
Sebum
Solid Phase Extraction
Thermodynamics
Triglycerides
Epidermis
Sebum
Cholesterol
Ceramides
Fatty Acids
Triglycerides
Lipid Bilayers
Thermodynamics
Solid Phase Extraction
Molecular Dynamics Simulation
02 Physical Sciences
03 Chemical Sciences
Chemical Physics
Publication Status: Published
Conference Place: England
Embargo Date: 2019-12-17
Online Publication Date: 2018-12-17
Appears in Collections:Faculty of Engineering
Chemistry
Chemical Engineering
Faculty of Natural Sciences



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