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Chemoresistance and the self-maintaining tumor microenvironment

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Title: Chemoresistance and the self-maintaining tumor microenvironment
Authors: Yeldag, G
Rice, A
Del Rio Hernandez, A
Item Type: Journal Article
Abstract: The progression of cancer is associated with alterations in the tumor microenvironment, including changes in extracellular matrix (ECM) composition, matrix rigidity, hypervascularization, hypoxia, and paracrine factors. One key malignant phenotype of cancer cells is their ability to resist chemotherapeutics, and elements of the ECM can promote chemoresistance in cancer cells through a variety of signaling pathways, inducing changes in gene expression and protein activity that allow resistance. Furthermore, the ECM is maintained as an environment that facilitates chemoresistance, since its constitution modulates the phenotype of cancer-associated cells, which themselves affect the microenvironment. In this review, we discuss how the properties of the tumor microenvironment promote chemoresistance in cancer cells, and the interplay between these external stimuli. We focus on both the response of cancer cells to the external environment, as well as the maintenance of the external environment, and how a chemoresistant phenotype emerges from the complex signaling network present.
Issue Date: 28-Nov-2018
Date of Acceptance: 27-Nov-2018
URI: http://hdl.handle.net/10044/1/66533
DOI: https://dx.doi.org/10.3390/cancers10120471
ISSN: 2072-6694
Publisher: MDPI AG
Journal / Book Title: Cancers
Volume: 10
Issue: 12
Copyright Statement: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 282051
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
chemoresistance
ECM
fibrosis
hypoxia
mechanosignaling
paracrine
hypervascularization
cancer stem cells
EPITHELIAL-MESENCHYMAL TRANSITION
CANCER-ASSOCIATED FIBROBLASTS
GROWTH-FACTOR-BETA
INTERSTITIAL FLUID PRESSURE
NF-KAPPA-B
HYPOXIA-INDUCIBLE FACTOR-1-ALPHA
ACTIVATED PROTEIN-KINASE
EXTRACELLULAR-MATRIX
BREAST-CANCER
TGF-BETA
Publication Status: Published
Appears in Collections:Faculty of Engineering
Bioengineering



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