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Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group

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Title: Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group
Authors: Schütz, K
Alecsandru, D
Grimbacher, B
Haddock, J
Bruining, A
Driessen, G
De Vries, E
Van Hagen, PM
Hartmann, I
Fraioli, F
Milito, C
Mitrevski, M
Quinti, I
Serra, G
Kelleher, P
Loebinger, M
Litzman, J
Postranecka, V
Thon, V
Babar, J
Condliffe, AM
Exley, A
Kumararatne, D
Screaton, N
Jones, A
Bondioni, MP
Lougaris, V
Plebani, A
Soresina, A
Sirignano, C
Spadaro, G
Galal, N
Gonzalez-Granado, LI
Dettmer, S
Stirling, R
Chapel, H
Lucas, M
Patel, S
Farber, C-M
Meyts, I
Banerjee, AK
Hackett, S
Hurst, JR
Warnatz, K
Gathmann, B
Baumann, U
Chest CT in Antibody Deficiency Group
Item Type: Journal Article
Abstract: Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency. Ffteen immunodeficiency centres from 9 countries evaluated chest CT scans of patients with ADS using a predefined list of potential findings including an extent score for bronchiectasis. Data of 282 patients with ADS were collected. Patients with common variable immunodeficiency disorders (CVID) comprised the largest subgroup (232 patients, 82.3%). Eighty percent of CVID patients had radiological evidence of bronchial pathology including bronchiectasis in 61%, bronchial wall thickening in 44% and mucus plugging in 29%. Bronchiectasis was detected in 44% of CVID patients aged less than 20 years. Cough was a better predictor for bronchiectasis than spirometry values. Delay of diagnosis as well as duration of disease correlated positively with presence of bronchiectasis. The use of consensus diagnostic criteria and a pre-defined list of bronchial pathologies allows for comparison of chest CT data in multicentre studies. Our data suggest a high prevalence of bronchial pathology in CVID due to late diagnosis or duration of disease.
Issue Date: 13-Dec-2018
Date of Acceptance: 26-Nov-2018
URI: http://hdl.handle.net/10044/1/66531
DOI: https://dx.doi.org/10.1007/s10875-018-0577-9
ISSN: 0271-9142
Publisher: Springer (part of Springer Nature)
Journal / Book Title: Journal of Clinical Immunology
Copyright Statement: © Springer Science+Business Media, LLC, part of Springer Nature 2018. The final publication is available at Springer via https://link.springer.com/article/10.1007%2Fs10875-018-0577-9
Keywords: CVID
Chest CT
bronchial pathology
bronchiectasis
primary antibody deficiency
Chest CT in Antibody Deficiency Group
1107 Immunology
Immunology
Publication Status: Published online
Conference Place: Netherlands
Embargo Date: 2019-12-13
Online Publication Date: 2018-12-13
Appears in Collections:National Heart and Lung Institute
Department of Medicine
Faculty of Medicine



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