Spotlight on avian pathology: fowlpox virus

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Title: Spotlight on avian pathology: fowlpox virus
Authors: Giotis, ES
Skinner, M
Item Type: Journal Article
Abstract: Fowlpox virus is the type species of an extensive and poorly-defined group of viruses isolated from more than 200 species of birds, together comprising the avipoxvirus genus of the poxvirus family. Long known as a significant poultry pathogen, vaccines developed in the early and middle years of the 20th century led to its effective eradication as a problem to commercial production in temperate climes in developed western countries (such that vaccination there is now far less common). Transmitted mechanically by biting insects, it remains problematic, causing significant losses to all forms of production (from back-yard, through extensive to intensive commercial flocks), in tropical climes where control of biting insects is difficult. In these regions, vaccination (via intra-dermal or subcutaneous, and increasingly in ovo, routes) remains necessary. Although there is no evidence that more than a single serotype exists, there are poorly-described reports of outbreaks in vaccinated flocks. Whether this is due to inadequate vaccination or penetrance of novel variants remains unclear. Some such outbreaks have been associated with strains carrying endogenous, infectious proviral copies of the retrovirus, reticulo-endotheliosis virus (REV), which might represent a pathotypic (if not newly emerging) variant in the field. Until more is known about the phylogenetic structure of the avipoxvirus genus (by more widespread genome sequencing of isolates from different species of birds) it remains difficult to ascertain the risk of novel avipoxviruses emerging from wild birds (and/or by recombination/mutation) to infect farmed poultry.
Issue Date: 18-Dec-2018
Date of Acceptance: 26-Nov-2018
ISSN: 0307-9457
Publisher: Taylor & Francis
Journal / Book Title: Avian Pathology
Copyright Statement: © 2018 Houghton Trust Ltd. This is an Accepted Manuscript of an article published by Taylor & Francis in Avian Pathology on 3 Dec 2018, available online:
Sponsor/Funder: Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: BB/K002465/1
Keywords: Fowlpox virus
Fowlpox virus
Infection Control
Emerging infections
0605 Microbiology
0707 Veterinary Sciences
Veterinary Sciences
Publication Status: Published online
Embargo Date: 2019-12-03
Open Access location:
Online Publication Date: 2018-12-03
Appears in Collections:Department of Medicine
Faculty of Medicine

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