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Lung homeostasis: influence of age, microbes, and the immune system

Title: Lung homeostasis: influence of age, microbes, and the immune system
Authors: Lloyd, CM
Marsland, BJ
Item Type: Journal Article
Abstract: Pulmonary immune homeostasis is maintained by a network of tissue-resident cells that continually monitor the external environment, and in health, instruct tolerance to innocuous inhaled particles while ensuring that efficient and rapid immune responses can be mounted against invading pathogens. Here we review the multiple pathways that underlie effective lung immunity in health, and discuss how these may be affected by external environmental factors and contribute to chronic inflammation during disease. In this context, we examine the current understanding of the impact of the microbiota in immune development and function and in the setting of the threshold for immune responses that maintains the balance between tolerance and chronic inflammation in the lung. We propose that host interactions with microbes are critical for establishing the immune landscape of the lungs.
Issue Date: 18-Apr-2017
Date of Acceptance: 1-Apr-2017
URI: http://hdl.handle.net/10044/1/66461
DOI: https://dx.doi.org/10.1016/j.immuni.2017.04.005
ISSN: 1074-7613
Publisher: Elsevier
Start Page: 549
End Page: 561
Journal / Book Title: Immunity
Volume: 46
Issue: 4
Copyright Statement: © 2017 Elsevier Inc.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Wellcome Trust
Funder's Grant Number: G1000758
G1000758
107059/Z/15/Z
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
INNATE LYMPHOID-CELLS
CHAIN FATTY-ACIDS
REGULATORY T-CELLS
PLASMACYTOID DENDRITIC CELLS
OBSTRUCTIVE PULMONARY-DISEASE
ALLERGIC AIRWAY INFLAMMATION
TISSUE-RESIDENT MACROPHAGES
MEMORY CD8+T CELLS
1,401 US CHILDREN
MHC CLASS-I
Aging
Animals
Homeostasis
Host-Pathogen Interactions
Humans
Immune System
Inflammation
Lung
Microbiota
Models, Immunological
Lung
Immune System
Animals
Humans
Inflammation
Aging
Homeostasis
Models, Immunological
Host-Pathogen Interactions
Microbiota
Science & Technology
Life Sciences & Biomedicine
Immunology
INNATE LYMPHOID-CELLS
CHAIN FATTY-ACIDS
REGULATORY T-CELLS
PLASMACYTOID DENDRITIC CELLS
OBSTRUCTIVE PULMONARY-DISEASE
ALLERGIC AIRWAY INFLAMMATION
TISSUE-RESIDENT MACROPHAGES
MEMORY CD8+T CELLS
1,401 US CHILDREN
MHC CLASS-I
1107 Immunology
Immunology
Publication Status: Published
Open Access location: https://www.cell.com/immunity/fulltext/S1074-7613(17)30138-3?_returnURL=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761317301383%3Fshowall%3Dtrue
Online Publication Date: 2017-04-19
Appears in Collections:National Heart and Lung Institute



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