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Detection of microRNA biomarkers via inhibition of DNA-mediated liposome fusion

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Title: Detection of microRNA biomarkers via inhibition of DNA-mediated liposome fusion
Authors: Jumeaux, C
Kim, E
Howes, P
Kim, H
Chandrawati, R
Stevens, M
Item Type: Journal Article
Abstract: We report the specific and sensitive detection of microRNA using an inverse DNA-mediated liposome fusion assay. This assay is homogeneous, and does not require washing, separation, or enzyme-associated amplification steps. By fine-tuning the surface functionalisation of the liposomes, liposome concentration, and assay temperature, we demonstrated a sub-nanomolar limit of detection for the target.
Issue Date: 21-Nov-2018
Date of Acceptance: 15-Nov-2018
URI: http://hdl.handle.net/10044/1/66421
DOI: https://dx.doi.org/10.1039/C8NA00331A
ISSN: 2516-0230
Publisher: Royal Society of Chemistry
Journal / Book Title: Nanoscale Advances
Copyright Statement: © The Royal Society of Chemistry 2018. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/)
Sponsor/Funder: Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/K031953/1
EP/K020641/1
Publication Status: Published online
Online Publication Date: 2018-11-21
Appears in Collections:Faculty of Engineering
Materials
Faculty of Natural Sciences



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