Impact of short-term traffic-related air pollution on the metabolome – results from two metabolome-wide experimental studies

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Title: Impact of short-term traffic-related air pollution on the metabolome – results from two metabolome-wide experimental studies
Authors: Chadeau, M
Van Veldhoven, C
Kiss, A
Keski-Rahkonen, P
Robinot, N
Scalbert, A
Cullinan, P
Chung, KF
Collins, P
Sinharay, R
Barratt, B
Nieuwenhuijsen, M
Ambros Rodoreda, A
Carrasco-Turigas, G
Vlaanderen, J
Vermeulen, R
Kyrtopoulous, S
Ponzi, E
Vineis, P
Item Type: Journal Article
Abstract: Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford Street II (London) and the TAPAS II (Barcelona) studies, where volunteers were allocated to high or low air pollution exposures. The two locations represent different exposure scenarios, with Oxford Street characterized by diesel vehicles and Barcelona by normal mixed urban traffic. Levels of five and four pollutants were measured, respectively, using personal exposure monitoring devices. Serum samples were used for metabolomic profiling. The association between TRAP and levels of each metabolic feature was assessed. All pollutant levels were significantly higher at the high pollution sites. 29 and 77 metabolic features were associated with at least one pollutant in the Oxford Street II and TAPAS II studies, respectively, which related to 17 and 30 metabolic compounds. Little overlap was observed across pollutants for metabolic features, suggesting that different pollutants may affect levels of different metabolic features. After observing the annotated compounds, the main pathway suggested in Oxford Street II in association with NO2 was the acyl-carnitine pathway, previously found to be associated with cardio-respiratory disease. No overlap was found between the metabolic features identified in the two studies.
Issue Date: 1-Feb-2019
Date of Acceptance: 14-Nov-2018
URI: http://hdl.handle.net/10044/1/66413
DOI: https;//dx.doi.org/10.1016/j.envint.2018.11.034
ISSN: 0160-4120
Publisher: Elsevier
Start Page: 124
End Page: 131
Journal / Book Title: Environment International
Volume: 123
Copyright Statement: © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 308610
Keywords: Science & Technology
Life Sciences & Biomedicine
Environmental Sciences
Environmental Sciences & Ecology
Traffic related air pollution
Metabolomics
Randomized crossover trials
PARTICULATE MATTER
OXIDATIVE STRESS
EXPOSURE
RESPONSES
ASSOCIATION
CARNITINE
MD Multidisciplinary
Publication Status: Published
Online Publication Date: 2018-12-03
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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