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Novel technologies in the treatment and monitoring of advanced and relapsed epithelial ovarian cancer

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Title: Novel technologies in the treatment and monitoring of advanced and relapsed epithelial ovarian cancer
Authors: Cunnea, P
Gowers, S
Moore, JE
Drakakis, E
Boutelle, M
Fotopoulou, C
Item Type: Journal Article
Abstract: Epithelial ovarian cancer (EOC) is the fifth most common cause of cancer death in females in the UK. It has long been recognized to be a set of heterogeneous diseases, with high grade serous being the most common subtype. The majority of patients with EOC present at an advanced stage (FIGO III–IV), and have the largest risk for disease recurrence from which a high percentage will develop resistance to chemotherapy. Despite continual advances in diagnostics, imaging, surgery and treatment of EOC, there has been little variation in the survival rates for patients with EOC. In this review we will introduce novel bioengineering advances in modelling the lymphatic system and real-time tissue monitoring to improve the clinical and therapeutic outcome for patients with EOC. We discuss the advent of the non-invasive 'liquid biopsy' in the surveillance of patients undergoing treatment and follow-up. Finally, we present new bioengineering advances for palliative care of patients to lessen symptoms of patients with ascites and improve quality of life.
Issue Date: 1-Mar-2017
Date of Acceptance: 30-Jan-2017
URI: http://hdl.handle.net/10044/1/66124
DOI: https://dx.doi.org/10.1088/2057-1739/aa5cf1
ISSN: 2057-1739
Publisher: IOP Publishing
Journal / Book Title: Convergent Science Physical Oncology
Volume: 3
Issue: 1
Copyright Statement: © 2017 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article accepted for publication in [insert name of journal]. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at https://onlinelibrary.wiley.com/doi/full/10.1002/9781118476406.emoe527
Sponsor/Funder: Ovarian Cancer Action
Funder's Grant Number: N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
bioengineering
treatment
epithelial ovarian cancer
CIRCULATING TUMOR-CELLS
RAPID SAMPLING MICRODIALYSIS
RESISTANT PROSTATE-CANCER
PLASMA DNA
MOLECULAR CHARACTERIZATION
ONLINE MICRODIALYSIS
PROGNOSTIC-FACTOR
RANDOMIZED-TRIAL
DYNAMIC CHANGES
BLOOD
Publication Status: Published
Article Number: UNSP 013002
Online Publication Date: 2017-02-23
Appears in Collections:Bioengineering
Division of Surgery
Division of Cancer
Faculty of Medicine



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