Role of stem cells in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema

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Title: Role of stem cells in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema
Authors: Coppolino, I
Ruggeri, P
Nucera, F
Cannavò, MF
Adcock, I
Girbino, G
Caramori, G
Item Type: Journal Article
Abstract: There are only few human translational studies performed in the area of stem cell research in patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary emphysema. Before progress to clinical trials with stem cells we strongly believe that more human translational studies are essential, otherwise, the clinical rationale would be solely based on limited in vitro and animal studies. In the future, stem cell therapy could be a treatment for this incurable disease. As of now, stem cell therapy is still to be considered as an area of active research, lacking any strong rationale for performing clinical trials in COPD. Although stem cells would be likely to represent a heterogeneous population of cells, the different cell subsets and their importance in the pathogenesis of the different clinical phenotypes need to be fully characterised before progressing to clinical trials. Moreover, the potential side effects of stem cell therapy are underestimated. We should not ignore that some of the most deadly neoplasms are arising from stem cells.
Issue Date: 23-Nov-2018
Date of Acceptance: 23-Oct-2018
URI: http://hdl.handle.net/10044/1/66001
DOI: https://dx.doi.org/10.1080/15412555.2018.1536116
ISSN: 1541-2555
Publisher: Taylor & Francis
Start Page: 536
End Page: 556
Journal / Book Title: COPD: Journal of Chronic Obstructive Pulmonary Disease
Volume: 15
Issue: 5
Copyright Statement: © 2018 Taylor & Francis Group, LLC. This is an Accepted Manuscript of an article published by Taylor & Francis in COPD: Journal of Chronic Obstructive Pulmonary Disease on 23 Nov 2018, available online: https://www.tandfonline.com/doi/full/10.1080/15412555.2018.1536116
Keywords: COPD
Stem cell
adipose tissue-derived stem cells
endothelial progenitor cells
fibrocytes
lung
mesenchymal stem cells
pulmonary emphysema
Respiratory System
Publication Status: Published
Conference Place: England
Embargo Date: 2019-11-23
Online Publication Date: 2018-11-23
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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