Emerging technologies for low-cost, rapid vaccine manufacture

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Title: Emerging technologies for low-cost, rapid vaccine manufacture
Authors: Kis, Z
Shattock, R
Shah, N
Kontoravdi, K
Item Type: Journal Article
Abstract: To stop the spread of future epidemics and meet infant vaccination demands in low‐ and middle‐income countries, flexible, rapid and low‐cost vaccine development and manufacturing technologies are required. Vaccine development platform technologies that can produce a wide range of vaccines are emerging, including: a) humanized, high‐yield yeast recombinant protein vaccines; b) insect cell‐baculovirus ADDomer vaccines; c) Generalized Modules for Membrane Antigens (GMMA) vaccines; d) RNA vaccines. Herein, existing and future platforms are assessed in terms of addressing challenges of scale, cost, and responsiveness. To assess the risk and feasibility of the four emerging platforms, the following six metrics are applied: 1) technology readiness; 2) technological complexity; 3) ease of scale‐up; 4) flexibility for the manufacturing of a wide range of vaccines; 5) thermostability of the vaccine product at tropical ambient temperatures; and 6) speed of response from threat identification to vaccine deployment. The assessment indicated that technologies in the order of increasing feasibility and decreasing risk are the yeast platform, ADDomer platform, followed by RNA and GMMA platforms. The comparative strengths and weaknesses of each technology are discussed in detail, illustrating the associated development and manufacturing needs and priorities.
Issue Date: 10-Jan-2019
Date of Acceptance: 30-Oct-2018
URI: http://hdl.handle.net/10044/1/65963
DOI: https://dx.doi.org/10.1002/biot.201800376
ISSN: 1860-6768
Publisher: Wiley
Journal / Book Title: Biotechnology Journal
Volume: 14
Copyright Statement: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Kis, Z. , Shattock, R. , Shah, N. and Kontoravdi, C. (2019), Emerging Technologies for Low‐Cost, Rapid Vaccine Manufacture. Biotechnol. J., 14: 1800376., which has been published in final form at https://dx.doi.org/10.1002/biot.201800376
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/R013764/1
Keywords: RNA vaccines
bacterial outer-membrane vesicle vaccines
insect cell-baculovirus vaccine manufacturing
vaccine manufacturing technology assessment
yeast-based vaccine manufacturing platform
1002 Environmental Biotechnology
1003 Industrial Biotechnology
1004 Medical Biotechnology
Biotechnology
Publication Status: Published
Embargo Date: 2019-12-10
Article Number: 1800376
Online Publication Date: 2018-12-10
Appears in Collections:Faculty of Engineering
Centre for Environmental Policy
Chemical Engineering
Department of Medicine
Faculty of Medicine
Faculty of Natural Sciences



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