Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa

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Title: Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa
Author(s): Sherrard-Smith, E
Griffin, J
Winskill, P
Corbel, V
Pennetier, C
Djénontin, A
Moore, S
Richardson, J
Müller, P
Edi, C
Protopopoff, N
Oxborough, R
Agossa, F
N'Guessan, R
Rowland, M
Churcher, T
Item Type: Journal Article
Abstract: Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel non-pyrethroid IRS products, with contrasting impacts, have been introduced. There is an urgent need to better assess product efficacy to help decision makers choose effective and relevant tools for mosquito control. Here we use experimental hut trial data to characterise the entomological efficacy of widely-used, novel IRS insecticides. We quantify their impact against pyrethroid-resistant mosquitoes and use a Plasmodium falciparum transmission model to predict the public health impact of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including bednet use, seasonality, endemicity and pyrethroid resistance status of local mosquito populations. We provide a framework to help decision makers evaluate IRS product effectiveness.
Publication Date: 26-Nov-2018
Date of Acceptance: 25-Oct-2018
URI: http://hdl.handle.net/10044/1/65787
DOI: https://dx.doi.org/10.1038/s41467-018-07357-w
ISSN: 2041-1723
Publisher: Nature Publishing Group
Journal / Book Title: Nature Communications
Volume: 9
Sponsor/Funder: IVCC
Wellcome Trust
Funder's Grant Number: N/A
200222/B/15/Z
Copyright Statement: © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article ’ s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article ’ s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
INSECTICIDE RESISTANCE
PIRIMIPHOS-METHYL
VECTOR CONTROL
MALARIA
BENIN
POPULATIONS
MOSQUITOS
COVERAGE
BEHAVIOR
TRENDS
Africa
Animals
Culicidae
Insecticide-Treated Bednets
Insecticides
Malaria
Plasmodium falciparum
Public Health
Pyrethrins
Randomized Controlled Trials as Topic
Time Factors
Animals
Culicidae
Plasmodium falciparum
Malaria
Pyrethrins
Insecticides
Public Health
Time Factors
Africa
Randomized Controlled Trials as Topic
Insecticide-Treated Bednets
MD Multidisciplinary
Publication Status: Published
Article Number: ARTN 4982
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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