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Gated single-molecule transport in double-barreled nanopores

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Title: Gated single-molecule transport in double-barreled nanopores
Authors: Xue, L
Cadinu, P
Paulose Nadappuram, B
Kang, M
Ma, Y
Korchev, Y
Ivanov, A
Edel, J
Item Type: Journal Article
Abstract: Single-molecule methods have been rapidly developing with the appealing prospect of transforming conventional ensemble-averaged analytical techniques. However, challenges remain especially in improving detection sensitivity and controlling molecular transport. In this article, we present a direct method for the fabrication of analytical sensors that combine the advantages of nanopores and field-effect transistors for simultaneous label-free single-molecule detection and manipulation. We show that these hybrid sensors have perfectly aligned nanopores and field-effect transistor components making it possible to detect molecular events with up to near 100% synchronization. Furthermore, we show that the transport across the nanopore can be voltage-gated to switch on/off translocations in real time. Finally, surface functionalization of the gate electrode can also be used to fine tune transport properties enabling more active control over the translocation velocity and capture rates.
Issue Date: 7-Nov-2018
Date of Acceptance: 15-Oct-2018
URI: http://hdl.handle.net/10044/1/65579
DOI: https://dx.doi.org/10.1021/acsami.8b13721
ISSN: 1944-8244
Publisher: American Chemical Society
Start Page: 38621
End Page: 38629
Journal / Book Title: ACS Applied Materials and Interfaces
Volume: 10
Issue: 44
Copyright Statement: © 2018 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Commission of the European Communities
Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: EP/P011985/1
724300
BB/R022429/1
Keywords: Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
single-molecule sensing
nanopore
voltage gating
functionalized gate
tunable nanoscale transport
nanofluidic field-effect transistor
SOLID-STATE NANOPORES
NANOFLUIDIC TRANSISTORS
GRAPHENE NANORIBBON
CURRENT SIGNALS
IONIC CURRENT
CELL ANALYSIS
DNA
TRANSLOCATION
SENSORS
NANOPROBES
0904 Chemical Engineering
0303 Macromolecular And Materials Chemistry
0306 Physical Chemistry (Incl. Structural)
Publication Status: Published
Online Publication Date: 2018-10-15
Appears in Collections:Chemistry
Faculty of Natural Sciences



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