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Giant flagellins form thick flagellar filaments in two species of marine gamma-proteobacteria

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Title: Giant flagellins form thick flagellar filaments in two species of marine gamma-proteobacteria
Authors: Thomson, NM
Ferreira, JL
Matthews-Palmer, TR
Beeby, M
Pallen, MJ
Item Type: Journal Article
Abstract: Flagella, the primary means of motility in bacteria, are helical filaments that function as microscopic propellers composed of thousands of copies of the protein flagellin. Here, we show that many bacteria encode “giant” flagellins, greater than a thousand amino acids in length, and that two species that encode giant flagellins, the marine γ-proteobacteria Bermanella marisrubri and Oleibacter marinus, produce monopolar flagellar filaments considerably thicker than filaments composed of shorter flagellin monomers. We confirm that the flagellum from B. marisrubri is built from its giant flagellin. Phylogenetic analysis reveals that the mechanism of evolution of giant flagellins has followed a stepwise process involving an internal domain duplication followed by insertion of an additional novel insert. This work illustrates how “the” bacterial flagellum should not be seen as a single, idealised structure, but as a continuum of evolved machines adapted to a range of niches.
Issue Date: 21-Nov-2018
Date of Acceptance: 15-Oct-2018
URI: http://hdl.handle.net/10044/1/65570
DOI: https://dx.doi.org/10.1371/journal.pone.0206544
ISSN: 1932-6203
Publisher: Public Library of Science (PLoS)
Journal / Book Title: PLoS ONE
Volume: 13
Issue: 11
Copyright Statement: © 2018 Thomson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: MR/P019374/1
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
SEQUENCE ALIGNMENT
PERFORMANCE
MOTILITY
MOTORS
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
SEQUENCE ALIGNMENT
PERFORMANCE
MOTILITY
MOTORS
MD Multidisciplinary
General Science & Technology
Publication Status: Published
Article Number: ARTN e0206544
Online Publication Date: 2019-11-21
Appears in Collections:Faculty of Natural Sciences



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