Senescent cells: a new Achilles' heel to exploit for cancer medicine?

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Title: Senescent cells: a new Achilles' heel to exploit for cancer medicine?
Authors: Zhang, B
Lam, E
Sun, Y
Item Type: Journal Article
Abstract: Cellular senescence is a typical tumor‐suppressive mechanism that restricts the proliferation of premalignant cells. However, mounting evidence suggests that senescent cells, which also persist in vivo, can promote the incidence of aging‐related disorders principally via the senescence‐associated secretory phenotype (SASP), among which cancer is particularly devastating. Despite the beneficial effects of the SASP on certain physiological events such as wound healing and tissue repair, more studies have demonstrated that senescent cells can substantially contribute to pathological conditions and accelerate disease exacerbation, particularly cancer resistance, relapse and metastasis. To limit the detrimental properties while retaining the beneficial aspects of senescent cells, research advancements that support screening, design and optimization of anti‐aging therapeutic agents are in rapid progress in the setting of prospective development of clinical strategies, which together represent a new wave of efforts to control human malignancies or mitigate degenerative complications.
Issue Date: Feb-2019
Date of Acceptance: 15-Oct-2018
URI: http://hdl.handle.net/10044/1/65560
DOI: https://doi.org/10.1111/acel.12875
ISSN: 1474-9726
Publisher: Wiley Open Access
Journal / Book Title: Aging Cell
Volume: 18
Issue: 1
Copyright Statement: © 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Cancer Research UK
Breast Cancer Care & Breast Cancer Now
Breast Cancer Care & Breast Cancer Now
Funder's Grant Number: 12011
2012NovemberPhD016
2012MayPR070
Keywords: aging-related diseases
cancer
cellular senescence
clinical trial
senescence-associated secretory phenotype
senolytics
Developmental Biology
11 Medical and Health Sciences
06 Biological Sciences
Publication Status: Published
Article Number: e12875
Online Publication Date: 2018-11-19
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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