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Proteomic studies reveal disrupted in schizophrenia 1 as a player in both neurodevelopment and synaptic function

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Title: Proteomic studies reveal disrupted in schizophrenia 1 as a player in both neurodevelopment and synaptic function
Authors: Ramos, A
Rodríguez-Seoane, C
Rosa, I
Gorroño-Etxebarria, I
Alonso, J
Veiga, S
Korth, C
Kypta, R
García, Á
Requena, J
Item Type: Journal Article
Abstract: A balanced chromosomal translocation disrupting DISC1 (Disrupted in Schizophrenia 1) gene has been linked to psychiatric diseases, such as major depression, bipolar disorder and schizophrenia. Since the discovery of this translocation, many studies have focused on understating the role of the truncated isoform of DISC1, hypothesizing that the gain of function of this protein could be behind the neurobiology of mental conditions, but not so many studies have focused in the mechanisms impaired due to its loss of function. For that reason, we performed an analysis on the cellular proteome of primary neurons in which DISC1 was knocked down with the goal of identifying relevant pathways directly affected by DISC1 loss of function. Using an unbiased proteomic approach, we found that the expression of 31 proteins related to neurodevelopment (e.g., CRMP-2, stathmin) and synaptic function (e.g., MUNC-18, NCS-1) is altered by DISC1 in primary mouse neurons. Hence, this study reinforces the idea that DISC1 is a unifying regulator of both neurodevelopment and synaptic function, thereby providing a link between these two key anatomical and cellular circuitries.
Issue Date: 31-Jan-2019
Date of Acceptance: 24-Dec-2018
URI: http://hdl.handle.net/10044/1/65481
DOI: https://dx.doi.org/10.3390/ijms20010119
ISSN: 1422-0067
Publisher: MDPI AG
Journal / Book Title: International Journal of Molecular Sciences
Volume: 20
Issue: 1
Copyright Statement: © 2018 The Author(s). This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0 - https://creativecommons.org/licenses/by/4.0/).
Keywords: 0399 Other Chemical Sciences
0604 Genetics
0699 Other Biological Sciences
Chemical Physics
Publication Status: Published
Open Access location: https://www.mdpi.com/1422-0067/20/1/119
Article Number: 119
Online Publication Date: 2018-12-29
Appears in Collections:Division of Surgery
Division of Cancer



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