Identifying the optimal regional predictor of right ventricular global function: a high resolution 3D cardiac magnetic resonance study

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Title: Identifying the optimal regional predictor of right ventricular global function: a high resolution 3D cardiac magnetic resonance study
Authors: Dawes, T
Simoes Monteiro de Marvao, A
Shi, W
Rueckert, D
Cook, S
O'Regan, D
Item Type: Journal Article
Abstract: Right ventricular (RV) function has prognostic value in acute, chronic and peri‐operative disease, although the complex RV contractile pattern makes rapid assessment difficult. Several two‐dimensional (2D) regional measures estimate RV function, however the optimal measure is not known. High‐resolution three‐dimensional (3D) cardiac magnetic resonance cine imaging was acquired in 300 healthy volunteers and a computational model of RV motion created. Points where regional function was significantly associated with global function were identified and a 2D, optimised single‐point marker (SPM‐O) of global function developed. This marker was prospectively compared with tricuspid annular plane systolic excursion (TAPSE), septum‐freewall displacement (SFD) and their fractional change (TAPSE‐F, SFD‐F) in a test cohort of 300 patients in the prediction of RV ejection fraction. RV ejection fraction was significantly associated with systolic function in a contiguous 7.3 cm2 patch of the basal RV freewall combining transverse (38%), longitudinal (35%) and circumferential (27%) contraction and coinciding with the four‐chamber view. In the test cohort, all single‐point surrogates correlated with RV ejection fraction (p < 0.010), but correlation (R) was higher for SPM‐O (R = 0.44, p < 0.001) than TAPSE (R = 0.24, p < 0.001) and SFD (R = 0.22, p < 0.001), and non‐significantly higher than TAPSE‐F (R = 0.40, p < 0.001) and SFD‐F (R = 0.43, p < 0.001). SPM‐O explained more of the observed variance in RV ejection fraction (19%) and predicted it more accurately than any other 2D marker (median error 2.8 ml vs 3.6 ml, p < 0.001). We conclude that systolic motion of the basal RV freewall predicts global function more accurately than other 2D estimators. However, no markers summarise 3D contractile patterns, limiting their predictive accuracy.
Issue Date: 14-Nov-2018
Date of Acceptance: 5-Oct-2018
URI: http://hdl.handle.net/10044/1/65231
DOI: https://dx.doi.org/10.1111/anae.14494
ISSN: 0003-2409
Publisher: Wiley
Start Page: 312
End Page: 320
Journal / Book Title: Anaesthesia
Volume: 74
Issue: 3
Copyright Statement: © 2018 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
British Heart Foundation
Wellcome Trust
Imperial College London
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: RD410
PG/12/27/29489
RDC04
RDB02
Keywords: cardiac morbidity: pre-operative factors
magnetic resonance imaging
right ventricular function
1103 Clinical Sciences
1109 Neurosciences
Anesthesiology
Publication Status: Published
Online Publication Date: 2018-11-14
Appears in Collections:Faculty of Engineering
Computing
Clinical Sciences
Imaging Sciences
National Heart and Lung Institute
Molecular Sciences
Faculty of Medicine



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