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Non-equilibrium correlations in minimal dynamical models of polymer copying

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Title: Non-equilibrium correlations in minimal dynamical models of polymer copying
Authors: Poulton, J
Wolde, PRT
Ouldridge, TE
Item Type: Journal Article
Abstract: Living systems produce "persistent" copies of information-carrying polymers, in which template and copy sequences remain correlated after physically decoupling. We identify a general measure of the thermodynamic efficiency with which these non-equilibrium states are created, and analyze the accuracy and efficiency of a family of dynamical models that produce persistent copies. For the weakest chemical driving, when polymer growth occurs in equilibrium, both the copy accuracy and, more surprisingly, the efficiency vanish. At higher driving strengths, accuracy and efficiency both increase, with efficiency showing one or more peaks at moderate driving. Correlations generated within the copy sequence, as well as between template and copy, store additional free energy in the copied polymer and limit the single-site accuracy for a given chemical work input. Our results provide insight in the design of natural self-replicating systems and can aid the design of synthetic replicators.
Issue Date: 5-Feb-2019
Date of Acceptance: 12-Dec-2018
URI: http://hdl.handle.net/10044/1/65125
DOI: https://dx.doi.org/10.1073/pnas.1808775116
ISSN: 0027-8424
Publisher: National Academy of Sciences
Start Page: 1946
End Page: 1951
Journal / Book Title: Proceedings of the National Academy of Sciences
Volume: 116
Issue: 6
Copyright Statement: © 2019 The Author(s). Published under the PNAS license (https://www.pnas.org/page/authors/licenses)
Sponsor/Funder: The Royal Society
Funder's Grant Number: UF150067
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
biophysics
stochastic processes
thermodynamics
information transmission
SELF-REPLICATION
INFORMATION
ORIGIN
cond-mat.stat-mech
MD Multidisciplinary
Publication Status: Published
Online Publication Date: 2019-02-05
Appears in Collections:Faculty of Engineering
Bioengineering



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