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Mouse H-2k-restricted cytotoxic T cells recognize antigenic determinants in both the HA1 and HA2 subunits of the influenza A/PR/8/34 hemagglutinin

Title: Mouse H-2k-restricted cytotoxic T cells recognize antigenic determinants in both the HA1 and HA2 subunits of the influenza A/PR/8/34 hemagglutinin
Authors: Gould, KG
Scotney, H
Townsend, AR
Bastin, J
Brownlee, GG
Item Type: Journal Article
Abstract: We have constructed two chimeric influenza hemagglutinin (HA) genes in which the HA1 and HA2 subunits of the HA molecule have been interchanged between influenza A/PR/8/34 (H1 subtype) and A/NT/60/68 (H3 subtype). These genes were used to construct recombinant vaccinia viruses that expressed intact chimeric HA. These recombinant viruses were used to test whether murine CTL recognize antigenic determinants in either the HA1, HA2, or both subunits. We found that both subunits of the HA molecule contain determinants for CTL. This implies that CTL have, at least in part, separate antigenic determinants from B lymphocytes, which recognize mainly epitopes within the HA1 subunit.
Issue Date: 1-Sep-1987
Date of Acceptance: 1-Sep-1987
URI: http://hdl.handle.net/10044/1/65099
DOI: https://dx.doi.org/10.1084/jem.166.3.693
ISSN: 0022-1007
Publisher: Rockefeller University Press
Start Page: 693
End Page: 701
Journal / Book Title: Journal of Experimental Medicine
Volume: 166
Issue: 3
Copyright Statement: © 1987 Rockefeller University Press.
Keywords: Animals
Antigens, Viral
DNA
DNA, Recombinant
Epitopes
Female
H-2 Antigens
Hemagglutinins
Influenza A virus
Mice
Mice, Inbred CBA
T-Lymphocytes, Cytotoxic
Vaccinia virus
11 Medical And Health Sciences
Immunology
Publication Status: Published
Conference Place: United States
Appears in Collections:Department of Medicine
Faculty of Medicine



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