A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes

Title: A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes
Authors: Gould, K
Cossins, J
Bastin, J
Brownlee, GG
Townsend, A
Item Type: Journal Article
Abstract: A recombinant vaccinia has been designed to express amino acids 366-379 of influenza nucleoprotein, previously shown to be the minimal epitope recognized by a class I-restricted cytotoxic T cell clone. Target cells infected with the recombinant vaccinia virus expressing this peptide are recognized by CTL as efficiently as target cells expressing the complete nucleoprotein. The results imply the existence of a peptide transport system that constitutively passes the products of degraded proteins from the cytoplasm into a membrane-bound compartment of the cell.
Issue Date: 1-Sep-1989
Date of Acceptance: 1-Sep-1989
URI: http://hdl.handle.net/10044/1/65095
DOI: https://dx.doi.org/10.1084/jem.170.3.1051
ISSN: 0022-1007
Publisher: Rockefeller University Press
Start Page: 1051
End Page: 1056
Journal / Book Title: Journal of Experimental Medicine
Volume: 170
Issue: 3
Copyright Statement: © 1989 Rockefeller University Press.
Keywords: Animals
Cytoplasm
Epitopes
Histocompatibility Antigens Class I
Influenza A virus
Mice
Mice, Inbred CBA
Nucleoproteins
Peptide Fragments
RNA-Binding Proteins
T-Lymphocytes, Cytotoxic
Vaccinia virus
Viral Core Proteins
Viral Proteins
T-Lymphocytes, Cytotoxic
Cytoplasm
Animals
Mice, Inbred CBA
Mice
Vaccinia virus
Influenza A virus
Peptide Fragments
RNA-Binding Proteins
Nucleoproteins
Viral Proteins
Viral Core Proteins
Histocompatibility Antigens Class I
Epitopes
Animals
Cytoplasm
Epitopes
Histocompatibility Antigens Class I
Influenza A virus
Mice
Mice, Inbred CBA
Nucleoproteins
Peptide Fragments
RNA-Binding Proteins
T-Lymphocytes, Cytotoxic
Vaccinia virus
Viral Core Proteins
Viral Proteins
11 Medical And Health Sciences
Immunology
Publication Status: Published
Conference Place: United States
Appears in Collections:Department of Medicine
Faculty of Medicine



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx