Antibody fragment and affibody immunoPET imaging agents: radiolabelling strategies and applications

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Title: Antibody fragment and affibody immunoPET imaging agents: radiolabelling strategies and applications
Authors: Fu, R
Carroll, L
Yahioglu, GK
Aboagye, E
Miller, P
Item Type: Journal Article
Abstract: Antibodies have long been recognised as potent vectors for carrying diagnostic medical radionuclides, contrast agents and optical probes to diseased tissue for imaging. The area of ImmunoPET combines the use of positron emission tomography (PET) imaging with antibodies to improve the diagnosis, staging and monitoring of diseases. Recent developments in antibody engineering and PET radiochemistry have led to a new wave of experimental ImmunoPET imaging agents that are based on a range of antibody fragments and affibodies. In contrast to full antibodies, engineered affibody proteins and antibody fragments such as minibodies, diabodies, single‐chain variable region fragments (scFvs), and nanobodies are much smaller but retain the essential specificities and affinities of full antibodies in addition to more desirable pharmacokinetics for imaging. Herein, recent key developments in the PET radiolabelling strategies of antibody fragments and related affibody molecules are highlighted, along with the main PET imaging applications of overexpressed antigen‐associated tumours and immune cells.
Issue Date: 6-Dec-2018
Date of Acceptance: 18-Sep-2018
URI: http://hdl.handle.net/10044/1/64964
DOI: https;//dx.doi.org/10.1002/cmdc.201800624
ISSN: 1860-7187
Publisher: Wiley
Start Page: 2466
End Page: 2478
Journal / Book Title: ChemMedChem
Volume: 13
Issue: 23
Copyright Statement: © 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the pre-peer reviewed version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1002/cmdc.201800624
Sponsor/Funder: Cancer Research UK
Funder's Grant Number: C2536/A16584
Keywords: PET imaging
affibodies
antibody fragments
cancer imaging
radiolabelling
0304 Medicinal And Biomolecular Chemistry
0305 Organic Chemistry
1115 Pharmacology And Pharmaceutical Sciences
Medicinal & Biomolecular Chemistry
Embargo Date: 2019-09-23
Online Publication Date: 2018-09-23
Appears in Collections:Division of Surgery
Chemistry
Catalysis and Advanced Materials
Division of Cancer
Faculty of Natural Sciences



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