The ERK and JNK pathways in the regulation of metabolic reprogramming

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Title: The ERK and JNK pathways in the regulation of metabolic reprogramming
Authors: Papa, S
Choy, PM
Bubici, C
Item Type: Journal Article
Abstract: Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes and tumor suppressors, leading to the constitutive activation of signaling pathways involved in cell growth. This metabolic reprogramming, known as aerobic glycolysis or the Warburg effect, allows tumor cells to sustain their fast proliferation and evade apoptosis. Interfering with oncogenic signaling pathways that regulate the Warburg effect in cancer cells has therefore become an attractive anticancer strategy. However, evidence for the occurrence of the Warburg effect in physiological processes has also been documented. As such, close consideration of which signaling pathways are beneficial targets and the effect of their inhibition on physiological processes are essential. The MAPK/ERK and MAPK/JNK pathways, crucial for normal cellular responses to extracellular stimuli, have recently emerged as key regulators of the Warburg effect during tumorigenesis and normal cellular functions. In this review, we summarize our current understanding of the roles of the ERK and JNK pathways in controlling the Warburg effect in cancer and discuss their implication in controlling this metabolic reprogramming in physiological processes and opportunities for targeting their downstream effectors for therapeutic purposes.
Issue Date: 28-Mar-2019
Date of Acceptance: 23-Oct-2018
URI: http://hdl.handle.net/10044/1/64781
DOI: https://doi.org/10.1038/s41388-018-0582-8
ISSN: 0950-9232
Publisher: Springer Nature
Start Page: 2223
End Page: 2240
Journal / Book Title: Oncogene
Volume: 38
Issue: 13
Copyright Statement: © 2018 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Oncology
Cell Biology
Genetics & Heredity
PYRUVATE-KINASE M2
AEROBIC GLYCOLYSIS
CELL-METABOLISM
GLUCOSE-METABOLISM
BRAF INHIBITION
DENDRITIC CELL
PROTEIN-KINASE
TUMOR-GROWTH
STEM-CELLS
CANCER
Animals
Cell Transformation, Neoplastic
Cellular Reprogramming
Energy Metabolism
Glycolysis
Humans
JNK Mitogen-Activated Protein Kinases
MAP Kinase Signaling System
Neoplasms
Animals
Humans
Neoplasms
Cell Transformation, Neoplastic
JNK Mitogen-Activated Protein Kinases
MAP Kinase Signaling System
Energy Metabolism
Glycolysis
Cellular Reprogramming
Oncology & Carcinogenesis
1112 Oncology and Carcinogenesis
1103 Clinical Sciences
Publication Status: Published
Conference Place: England
Open Access location: https://www.nature.com/articles/s41388-018-0582-8#article-info
Online Publication Date: 2018-11-28
Appears in Collections:Faculty of Medicine



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