Base-free, tunable, Au-catalyzed oxidative esterification of alcohols in continuous flow

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Title: Base-free, tunable, Au-catalyzed oxidative esterification of alcohols in continuous flow
Authors: Roberts, F
Richard, C
Zemichael, F
Hii, KM
Hellgardt, K
Brennan, C
Sale, D
Item Type: Journal Article
Abstract: Under continuous flow conditions, hydrogen peroxide oxidizes primary alcohols (cinnamyl alcohol, decenol, decanol and benzyl alcohol) in methanol over Au/TiO2, without the need for added base. While the allylic alcohols afforded conjugated aldehydes, aliphatic and benzylic alcohols afforded acids or esters. Selectivity for either product can be achieved by adjusting the reaction parameters. Kinetic studies revealed that the formation of the easter is faster than that of the acid, due to a greater pre-organization (larger ln A) attributed to the more favourable formation of the hemiacetal intermediate.
Issue Date: 1-Dec-2018
Date of Acceptance: 13-Sep-2018
ISSN: 2058-9883
Publisher: Royal Society of Chemistry
Start Page: 942
End Page: 948
Journal / Book Title: Reaction Chemistry and Engineering
Volume: 3
Issue: 6
Copyright Statement: © The Royal Society of Chemistry 2018. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (
Publication Status: Published
Online Publication Date: 2018-10-22
Appears in Collections:Chemistry
Catalysis and Advanced Materials
Chemical Engineering
Faculty of Natural Sciences

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