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Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Title: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
Authors: Stanaway, JD
Afshin, A
Gakidou, E
Lim, SS
Abate, D
Abate, KH
Abbafati, C
Abbasi, N
Abbastabar, H
Abd-Allah, F
Abdela, J
Abdelalim, A
Abdollahpour, I
Abdulkader, RS
Abebe, M
Abebe, Z
Abera, SF
Abil, OZ
Abraha, HN
Abrham, AR
Abu-Raddad, LJ
Abu-Rmeileh, NME
Accrombessi, MMK
Acharya, D
Acharya, P
Adamu, AA
Adane, AA
Adebayo, OM
Adedoyin, RA
Adekanmbi, V
Ademi, Z
Adetokunboh, O
Adib, MG
Admasie, A
Adsuar, JC
Afanvi, KA
Afarideh, M
Agarwal, G
Aggarwal, A
Aghayan, SA
Agrawal, A
Agrawal, S
Ahmadi, A
Ahmadi, M
Ahmadieh, H
Ahmed, MB
Aichour, AN
Aichour, I
Aichour, MTE
Akbari, ME
Akinyemiju, T
Akseer, N
Al-Aly, Z
Al-Eyadhy, A
Al-Mekhlafi, HM
Alandab, F
Alam, K
Alam, S
Alam, T
Alashi, A
Alavian, SM
Alene, KA
Ali, K
Ali, SM
Alijanzadeh, M
Alizadeh-Navaei, R
Aljunid, SM
Alkerwi, A
Alla, F
Alsharif, U
Altirkawi, K
Alvis-Guzman, N
Amare, AT
Ammar, W
Anber, NH
Anderson, JA
Andrei, CL
Androudi, S
Animut, MD
Anjomshoa, M
Ansha, MG
Anto, JM
Antonio, CAT
Anwari, P
Appiah, LT
Appiah, SCY
Arabloo, J
Aremu, O
Amlov, J
Artaman, A
Aryal, KK
Asayesh, H
Ataro, Z
Ausloos, M
Avokpaho, EFGA
Awasthi, A
Quintanilla, BPA
Ayer, R
Ayuk, TB
Azzopardi, PS
Babazadeff, A
Badali, H
Badawi, A
Balakrishnan, K
Bali, AG
Ball, K
Bellew, SH
Banach, M
Banoub, JAM
Barac, A
Barker-Collo, SL
Bamighausen, TW
Barrero, LH
Basu, S
Baune, BT
Bazargan-Hejazi, S
Bedi, N
Beghi, E
Behzadifar, M
Behzadifar, M
Bejoy, Y
Bekele, BB
Bekru, FT
Belay, E
Belay, YA
Bell, ML
Bello, AK
Bennett, DA
Bensenor, IM
Bergeron, G
Berhane, A
Bemabe, E
Bemstein, RS
Beuran, M
Beyranvand, T
Bhala, N
Bhalla, A
Bhattarai, S
Bhutta, ZA
Biadgo, B
Bijani, A
Bikbov, B
Bilano, V
Bililign, N
Bin Sayeed, MS
Bisanzio, D
Biswas, T
Bjorge, T
Blacker, BF
Bleyer, A
Borschmann, R
Bou-Orm, IR
Boufous, S
Bourne, R
Brady, OJ
Brauer, M
Brazinova, A
Breitborde, NJK
Brenner, H
Briko, AN
Britton, G
Brugha, T
Buchbindet, R
Burnett, RT
Busse, R
Butt, ZA
Cahill, LE
Cahuana-Hurtado, L
Campos-Nonato, IR
Cardenas, R
Carreras, G
Carrero, JJ
Carvalho, F
Castaneda-Orjuela, CA
Rivas, JC
Castro, F
Catala-Lopez, F
Causey, K
Cercy, KM
Cerin, E
Chaiah, Y
Chang, H-T
Chang, J-C
Chang, K-L
Charlson, FJ
Chattopadhyay, A
Chattu, VK
Chee, ML
Cheng, C-Y
Chew, A
Chiang, PP-C
Chimed-Ochir, O
Chin, KL
Chitheer, A
Choi, J-YJ
Chowdhury, R
Christensen, H
Christopher, DJ
Chung, S-C
Cicuttini, FM
Grillo, M
Cohen, AJ
Collado-Mateo, D
Cooper, C
Cooper, OR
Coresh, J
Cornaby, L
Cortesi, PA
Cortinovis, M
Costa, M
Cousin, E
Criqui, MH
Cromwell, EA
Cundiff, DK
Daba, AK
Dachew, BA
Dadi, AF
Damasceno, AAM
Dandona, L
Dandona, R
Darby, SC
Dargan, PI
Daryani, A
Das Gupta, R
Das Neves, J
Dasa, TT
Dash, AP
Davitoiu, DV
Davletov, K
De la Cruz-Gongora, V
De la Hoz, FP
De Leo, D
De Neve, J-W
Degenhardt, L
Deiparine, S
Dellavalle, RP
Demoz, GT
Denova-Gutierrez, E
Deribe, K
Dervenis, N
Deshpande, A
Jarlais, DCD
Dessie, GA
Deveber, GA
Dey, S
Dharmaratne, SD
Dhimal, M
Dinberu, MT
Ding, EL
Diro, HD
Djalalinia, S
Huyen, PD
Dokova, K
Doku, DT
La Doyle, K
Driscoll, TR
Dubey, M
Dubljanin, E
Duken, EE
Duncan, BB
Duraes, AR
Ebert, N
Ebrahimi, H
Ebrahimpour, S
Edvardsson, D
Elfiong, A
Eggen, AE
El Bcheraoui, C
El-Khatib, I
Elyazar, IR
Enayati, A
Endries, AY
Er, B
Erskine, HE
Eskandarieh, S
Esteghamati, A
Estep, K
Fakhim, H
Faramarzi, M
Fareed, M
Farid, TA
Farinha, CSES
Farioli, A
Faro, A
Farvid, MS
Farzaei, MH
Fatima, B
Fay, KA
Fazaeli, AA
Feigin, VL
Feigl, AB
Fereshtehnejad, S-M
Fernandes, E
Fernandes, JC
Ferrara, G
Ferrari, AJ
Ferreira, ML
Filip, I
Finger, JD
Fischer, F
Foigt, NA
Foreman, KJ
Fukumoto, T
Fullman, N
Furst, T
Furtado, JM
Futran, ND
Gall, S
Gallus, S
Gamkrelidze, A
Ganji, M
Garcia-Basteiro, AL
Gardner, WN
Gebre, AK
Gebremedhin, AT
Gebremichael, TG
Gelano, TF
Geleijnse, JM
Geramo, YCD
Gething, PW
Geese, KE
Ghadimi, R
Ghadiri, K
Falavarjani, KG
Ghasemi-Kasman, M
Ghimire, M
Ghosh, R
Ghoshal, AG
Giampaoli, S
Gill, PS
Gill, TK
Gillum, RF
Ginawi, IA
Giussani, G
Gnedovskaya, EV
Godwin, WW
Goli, S
Gomez-Dantes, H
Gona, PN
Gopalani, SV
Goulart, AC
Grada, A
Grams, ME
Grosso, G
Gugnani, HC
Guo, Y
Gupta, R
Gupta, R
Gupta, T
Gutierrez, RA
Gutierrez-Torres, DS
Haagsma, JA
Habtewold, TD
Hachinski, V
Hafezi-Nejad, N
Hagos, TB
Hailegiyorgis, TT
Hailu, GB
Haj-Mirzaian, A
Haj-Mirzaian, A
Hamadeh, RR
Hamidi, S
Handal, AJ
Hankey, GJ
Liao, Y
Harb, HL
Harikrishnan, S
Haro, JM
Hassankhani, H
Hassen, HY
Havmoeller, R
Hawley, CN
Hay, SI
Hedayatizadeh-Omran, A
Heibati, B
Heidari, B
Heidari, M
Hendrie, D
Henok, A
Heredia-Pi, I
Herteliu, C
Heydarpour, F
Heydarpour, S
Hibstu, DT
Higazi, TB
Hilawe, EH
Hoek, HW
Hoffiman, HJ
Hole, MK
Rad, EH
Hoogar, P
Hosgood, HD
Hosseini, SM
Hosseinzadeh, M
Hostiuc, M
Hostiuc, S
Hoy, DG
Hsairi, M
Hsiao, T
Hu, G
Ha, H
Huang, JJ
Hussen, MA
Huynh, CK
Iburg, KM
Ikeda, N
Ilesanmi, OS
Iqbal, U
Irvani, SSN
Irvine, CMS
Islam, SMS
Islami, F
Jackson, MD
Jacobsen, KH
Jahangiry, L
Jahanmehr, N
Jain, SK
Jakovljevic, M
James, SL
Jassal, SK
Jayatilleke, AU
Jeemon, P
Jha, RP
Jha, V
Ji, JS
Jonas, JB
Jonnagaddala, J
Shushtari, ZJ
Joshi, A
Jozwiak, JJ
Jurisson, M
Kabir, Z
Kahsay, A
Kalani, R
Kanchan, T
Kant, S
Kar, C
Karami, M
Matin, BK
Karch, A
Karema, C
Karimi, N
Karimi, SM
Kasaeian, A
Kassa, DH
Kassa, GM
Kassa, TD
Kassebaum, NJ
Katikireddi, SV
Kaul, A
Kawakami, N
Kazemi, Z
Karyani, AK
Kefale, AT
Keiyoro, PN
Kemp, GR
Kengne, AP
Keren, A
Kesavachandran, CN
Khader, YS
Khafaei, B
Khafaie, MA
Khajavi, A
Khalid, N
Khalil, IA
Khan, G
Khan, MS
Khan, MA
Khang, Y-H
Khater, MM
Khazaei, M
Khazaie, H
Khoja, AT
Khosravi, A
Khosravi, MH
Kiadaliri, AA
Kiirithio, DN
Kim, C-I
Kim, D
Kim, Y-E
Kim, YJ
Kimokoti, RW
Kinfh, Y
Kisa, A
Kissimova-Skarbek, K
Kivimaki, M
Knibbs, LD
Knudsen, AKS
Kochhar, S
Kokubo, Y
Kolola, T
Kopec, JA
Kosen, S
Koul, PA
Koyanagi, A
Kravchenko, MA
Krishan, K
Krohn, KJ
Kromhout, H
Defo, BK
Bicer, BK
Kumar, GA
Kumar, M
Kuzin, I
Kyu, HH
Lachat, C
Lad, DP
Lad, SD
Lafranconi, A
Lalloo, R
Lallukka, T
Lami, FH
Lang, JJ
Lansingh, VC
Larson, SL
Latifi, A
Lazarus, JV
Lee, PH
Leigh, J
Leili, M
Leshargie, CT
Leung, J
Levi, M
Lewycka, S
Li, S
Li, Y
Liang, J
Liang, X
Lian, Y
Liben, ML
Lim, L-L
Linn, S
Liu, S
Lodha, R
Logroscino, G
Lopez, AD
Lorkowski, S
Lotufo, PA
Lozano, R
Lucas, TCD
Lunevicius, R
Ma, S
Macarayan, ERK
Machado, IE
Madotto, F
Mai, HT
Majdan, M
Majdzadeh, R
Majeed, A
Malekzadeh, R
Malta, DC
Mamum, AA
Manda, A-L
Manguerra, H
Mansournia, MA
Mantovani, LG
Maravilla, JC
Marcenes, W
Marks, A
Martin, RV
Martins, SC
Martins-Melo, FR
Marz, W
Marzan, MB
Massenburg, BB
Mathur, MR
Mathur, P
Matsushita, K
Maulik, PK
Mazidi, M
McAlinden, C
McGrath, JJ
McKee, M
Mehrotra, R
Mehta, KM
Mehta, V
Meier, T
Mekonnen, FA
Melaku, YA
Melese, A
Melku, M
Memiah, PTN
Memish, ZA
Mendoza, W
Mengistu, DT
Mensah, GA
Mensink, GBM
Mereta, ST
Meretola, A
Meretoja, TJ
Mestrovic, T
Mezgebe, HB
Miazgowski, B
Miazgowski, T
Millear, AI
Miller, TR
Miller-Petrie, MK
Mini, GK
Mirarefin, M
Mirica, A
Mirrakhimov, EM
Misganaw, AT
Mitiku, H
Moazen, B
Mohajer, B
Mohammad, KA
Mohammadi, M
Mohammadifard, N
Mohammadnia-Afrouzi, M
Mohammed, S
Mohebi, F
Mokdad, AH
Molokhia, M
Momeniha, F
Monasta, L
Moodley, Y
Moradi, G
Moradi-Lakeh, M
Moradinazar, M
Moraga, P
Morawska, L
Morgado-Da-Costa, J
Morrison, SD
Moschos, MM
Mouodi, S
Mousavi, SM
Mozaffarian, D
Mruts, KB
Muche, AA
Muchie, KF
Mueller, UO
Muhammed, OS
Mukhopadhyay, S
Muller, K
Musa, KI
Mustafa, G
Nabhan, AF
Naghavi, M
Naheed, A
Nahvijou, A
Naik, G
Naik, N
Najafi, L
Nangia, V
Nansseu, JR
Nascimento, BR
Neal, B
Neamati, N
Negoi, IT
Negoi, RI
Neupane, S
Newton, CRJ
Ngunjiri, JV
Anh, QN
Nguyen, G
Ha, TN
Huong, LTN
Huong, TN
Minh, N
Nam, BN
Nichols, E
Nie, J
Ningrum, DNA
Nirayo, YL
Nishi, N
Nixon, MR
Nojomi, M
Nomura, S
Norheim, OF
Noroozi, M
Norrving, B
Noubiap, JJ
Nouri, HR
Shiadeh, MN
Nowroozi, MR
Nsoesie, EO
Nyasulu, PS
Obermeyer, CM
Odell, CM
Ofori-Asenso, R
Ogbo, FA
Oh, I-H
Oladimeji, O
Olagunju, AT
Olagunju, TO
Olivares, PR
Olsen, HE
Olusanya, BO
Olusanya, JO
Ong, KL
Ong, SK
Oren, E
Orpana, HM
Ortiz, A
Ota, E
Otstavnov, SS
Overland, S
Owolabi, MO
Pacella, MPAR
Pakhare, AP
Pakpour, AH
Pana, A
Panda-Jonas, S
Park, E-K
Parry, CDH
Parisian, H
Patel, S
Pati, S
Patil, ST
Patle, A
Patton, GC
Paudel, D
Paulson, KR
Ballesteros, WCP
Pearce, N
Pereira, A
Pereira, DM
Perico, N
Pesudovs, K
Petzold, M
Hai, QP
Phillips, MR
Pillay, JD
Piradov, MA
Pirsaheb, M
Pischon, T
Pishgar, F
Plana-Ripoll, O
Plass, D
Polinder, S
Polkinghorne, KR
Postma, MJ
Poulton, R
Pourshams, A
Poustchi, H
Prabhakaran, D
Prakash, S
Prasad, N
Purcell, CA
Purwar, MB
Qorbani, M
Radfar, A
Rafay, A
Rafiei, A
Rahim, F
Rahimi, Z
Rahimi-Movaghar, A
Rahimi-Movaghar, V
Rahman, M
Rahman, MHU
Rahman, MA
Rai, RK
Rajati, F
Rajsic, S
Raju, SB
Ram, U
Ranabhat, CL
Ranjan, P
Rath, GK
Rawaf, DL
Rawaf, S
Reddy, KS
Rehm, CD
Rehm, J
Reiner, RC
Reitsma, MB
Remuzzi, G
Renzaho, AMN
Resnikoff, S
Reynales-Shigematsu, LM
Rezaei, S
Ribeiro, ALP
Rivera, JA
Roba, KT
Rodrigues-Ramirez, S
Roever, L
Roman, Y
Ronfani, L
Roshandel, G
Rostami, A
Roth, GA
Rothenbacher, D
Roy, A
Rubagotti, E
Rushton, L
Sabanayagam, C
Sachdev, PS
Saddik, B
Sadeghi, E
Moghaddam, SS
Safari, H
Safari, Y
Safari-Faramani, R
Safdarian, M
Safi, S
Safiri, S
Sagar, R
Sahebkar, A
Sahraian, MA
Sajadi, HS
Salam, N
Salamati, P
Saleem, Z
Salimi, Y
Salimeadeh, H
Salomon, JA
Salvi, DD
Satz, I
Samy, AM
Sanabria, J
Sanchez-Nino, MD
Sanchez-Pimienta, TG
Sanders, T
Sang, Y
Santomauro, DF
Santos, IS
Santos, JV
Milicevic, MMS
Jose, BPS
Sardana, M
Sacker, AR
Sarmiento-Suarez, R
Sarrafzadegan, N
Sartorius, B
Sarvi, S
Sathian, B
Satpathy, M
Sawant, AR
Sawhney, M
Saylan, M
Sayyah, M
Schaeffner, E
Schmidt, MI
Schneider, IJC
Schottker, B
Schutte, AE
Schwehel, DC
Schwendicke, F
Scott, JG
Seedat, S
Sekerija, M
Sepanlou, SG
Serre, ML
Servan-Mori, E
Seyedmousavi, S
Shabaninejad, H
Shaddick, G
Shafieesabet, A
Shahbazi, M
Shaheen, AA
Shaikh, MA
Levy, TS
Shams-Beyranvand, M
Shamsi, M
Sharafi, H
Sharafi, K
Sharif, M
Sharif-Alhoseini, M
Sharifi, H
Sharma, J
Sharma, M
Sharma, R
She, J
Sheikh, A
Shi, P
Shibuya, K
Shiferaw, MS
Shigematsu, M
Shin, M-J
Shirt, R
Shirkoohi, R
Shiue, I
Shokraneh, F
Shoman, H
Shrime, MG
Shupler, MS
Si, S
Siabani, S
Sibai, AM
Siddiqi, TJ
Sigfusdottir, ID
Sigurvinsdottir, R
Silva, DAS
Silva, JP
Silveira, DGA
Singh, JA
Singh, NP
Singh, V
Sinha, DN
Skiadaresi, E
Skirbekk, V
Smith, DL
Smith, M
Sobaih, BH
Sobhani, S
Somayaji, R
Soofi, M
Sorensen, RJD
Soriano, JB
Soyiri, IN
Spinelli, A
Sposato, LA
Sreeramareddy, CT
Srinivasan, V
Starodubow, VI
Steckling, N
Stein, DJ
Stein, MB
Stevanovic, G
Stockfelt, L
Stokes, MA
Sturua, L
Subart, ML
Sudaryanto, A
Sufiyan, MB
Sulo, G
Sunguya, BF
Sur, PJ
Sykes, BI
Szoeke, CEI
Tabares-Seisdedos, R
Tabuchi, T
Tadakamadla, SK
Takahashi, K
Tandon, N
Tassew, SG
Tavakkoli, M
Taveira, N
Tehrani-Banihashemi, A
Tekalign, TG
Tekelemedhin, SW
Tekle, MG
Temesgen, H
Temsah, M-R
Temsah, O
Terkawi, AS
Tessema, B
Teweldemedhin, M
Thankappan, KR
Theis, A
Thirunavukkarasu, S
Thomas, HJ
Thomas, ML
Thomas, N
Thurston, GD
Tilahun, B
Tillmana, T
To, QG
Tobollik, M
Tonelli, M
Topor-Madry, R
Torre, AE
Tortajada-Girbes, M
Touvier, M
Tovani-Palone, MR
Towbin, JA
Tran, BX
Tran, KB
Truelsen, TC
Nu, TT
Tsadik, AG
Car, LT
Tuzcu, EM
Tymeson, HD
Tyrovolas, S
Ukwaja, KN
Ullah, I
Updike, RL
Usman, MS
Uthman, OA
Vaduganathan, M
Vaezi, A
Valdez, PR
Van Donkelaar, A
Varavikova, E
Varughese, S
Vasankari, TJ
Venkateswaran, V
Venketasubramanian, N
Villafaina, S
Violante, FS
Vladimirov, SK
Vlassov, V
Vollset, SE
Vos, T
Vbsoughi, K
Vu, GT
Vujcic, IS
Wagnew, FS
Waheed, Y
Waller, SG
Walson, JL
Wang, Y
Wang, Y
Wang, Y-P
Weiderpass, E
Weintraub, RG
Weldegebreal, F
Werdecker, A
Weiknah, AA
West, JJ
Westerman, R
Whiteford, HA
Widecka, J
Wijeratne, T
Winkler, AS
Wiyeh, AB
Wiysonge, CS
Wolfe, CDA
Wong, TY
Wu, S
Xavier, D
Xu, G
Yadgir, S
Yadollahpour, A
Jabbari, SHY
Yamada, T
Yan, LL
Yano, Y
Yaseri, M
Yasin, JY
Yeshanely, A
Yimer, EM
Yip, P
Yisma, E
Yonemoto, N
Yoon, S-J
Yotebieng, M
Younis, MZ
Yousefifard, M
Yu, C
Zaidi, Z
Bin Zaman, S
Zamani, M
Zavala-Arciniega, L
Zhang, AL
Zhang, H
Zhang, K
Thou, M
Zimsen, SM
Zodpey, S
Murray, CJL
Item Type: Journal Article
Abstract: Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk–outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk–outcome pairs, and new data on risk exposure levels and risk–outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk–outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017. Findings In 2017, 34·1 million (95% uncertainty interval [UI] 33·3–35·0) deaths and 1·21 billion (1·14–1·28) DALYs were attributable to GBD risk factors. Globally, 61·0% (59·6–62·4) of deaths and 48·3% (46·3–50·2) of DALYs were attributed to the GBD 2017 risk factors. When ranked by risk-attributable DALYs, high systolic blood pressure (SBP) was the leading risk factor, accounting for 10·4 million (9·39–11·5) deaths and 218 million (198–237) DALYs, followed by smoking (7·10 million [6·83–7·37] deaths and 182 million [173–193] DALYs), high fasting plasma glucose (6·53 million [5·23–8·23] deaths and 171 million [144–201] DALYs), high body-mass index (BMI; 4·72 million [2·99–6·70] deaths and 148 million [98·6–202] DALYs), and short gestation for birthweight (1·43 million [1·36–1·51] deaths and 139 million [131–147] DALYs). In total, risk-attributable DALYs declined by 4·9% (3·3–6·5) between 2007 and 2017. In the absence of demographic changes (ie, population growth and ageing), changes in risk exposure and risk-deleted DALYs would have led to a 23·5% decline in DALYs during that period. Conversely, in the absence of changes in risk exposure and risk-deleted DALYs, demographic changes would have led to an 18·6% increase in DALYs during that period. The ratios of observed risk exposure levels to exposure levels expected based on SDI (O/E ratios) increased globally for unsafe drinking water and household air pollution between 1990 and 2017. This result suggests that development is occurring more rapidly than are changes in the underlying risk structure in a population. Conversely, nearly universal declines in O/E ratios for smoking and alcohol use indicate that, for a given SDI, exposure to these risks is declining. In 2017, the leading Level 4 risk factor for age-standardised DALY rates was high SBP in four super-regions: central Europe, eastern Europe, and central Asia; north Africa and Middle East; south Asia; and southeast Asia, east Asia, and Oceania. The leading risk factor in the high-income super-region was smoking, in Latin America and Caribbean was high BMI, and in sub-Saharan Africa was unsafe sex. O/E ratios for unsafe sex in sub-Saharan Africa were notably high, and those for alcohol use in north Africa and the Middle East were notably low. Interpretation By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning.
Issue Date: 10-Nov-2018
Date of Acceptance: 1-Sep-2018
URI: http://hdl.handle.net/10044/1/64685
DOI: https://dx.doi.org/10.1016/S0140-6736(18)32225-6
ISSN: 0140-6736
Publisher: ELSEVIER SCIENCE INC
Start Page: 1923
End Page: 1994
Journal / Book Title: LANCET
Volume: 392
Issue: 10159
Copyright Statement: © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
CARDIOVASCULAR-DISEASES
TOBACCO CONTROL
BLOOD-PRESSURE
METAANALYSIS
CHOLESTEROL
ILLNESS
TRENDS
TRIAL
11 Medical And Health Sciences
Publication Status: Published
Online Publication Date: 2018-11-08
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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