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Role of mast cells and type 2 innate lymphoid (ILC2) cells in lung transplantation

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Title: Role of mast cells and type 2 innate lymphoid (ILC2) cells in lung transplantation
Authors: Mortaz, E
Amani, S
Mumby, S
Adcock, IM
Movassaghi, M
Folkerts, J
Garssen, J
Folkerts, G
Item Type: Journal Article
Abstract: The multifunctional role of mast cells (MCs) in the immune system is complex and has not fully been explored. MCs reside in tissues and mucous membranes such as the lung, digestive tract, and skin which are strategically located at interfaces with the external environment. These cells, therefore, will encounter external stimuli and pathogens. MCs modulate both the innate and the adaptive immune response in inflammatory disorders including transplantation. MCs can have pro- and anti-inflammatory functions, thereby regulating the outcome of lung transplantation through secretion of mediators that allow interaction with other cell types, particularly innate lymphoid cells (ILC2). ILC2 cells are a unique population of hematopoietic cells that coordinate the innate immune response against a variety of threats including infection, tissue damage, and homeostatic disruption. In addition, MCs can modulate alloreactive T cell responses or assist in T regulatory (Treg) cell activity. This paper outlines the current understanding of the role of MCs in lung transplantation, with a specific focus on their interaction with ILC2 cells within the engrafted organ.
Issue Date: 30-Oct-2018
Date of Acceptance: 14-Sep-2018
URI: http://hdl.handle.net/10044/1/64654
DOI: https://dx.doi.org/10.1155/2018/2785971
ISSN: 2314-7156
Publisher: Hindawi Publishing Corporation
Journal / Book Title: Journal of Immunology Research
Volume: 2018
Copyright Statement: © 2018 Esmaeil Mortaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 093080/Z/10/Z
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
CD4(+) T-CELLS
IMMUNE-RESPONSES
CHRONIC REJECTION
TISSUE-REPAIR
ALLOGRAFT DYSFUNCTION
PATHOLOGICAL ROLES
ALLERGIC DISEASE
STEM-CELL
TGF-BETA
INFLAMMATION
Publication Status: Published
Article Number: 2785971
Online Publication Date: 2018-10-30
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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