Highly sensitive and selective molecular probes for chromo-fluorogenic sensing of carbon monoxide in air, aqueous solution and cells

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Title: Highly sensitive and selective molecular probes for chromo-fluorogenic sensing of carbon monoxide in air, aqueous solution and cells
Authors: Toscani, A
Marín-Hernández, C
Robson, J
Chua, E
Dingwall, P
White, A
Sancenón, F
De la Torre, C
Martínez-Máñez, R
Wilton-Ely, J
Item Type: Journal Article
Abstract: Optical sensing offers a low‐cost and effective means to sense carbon monoxide in air and in solution. This contribution reports the synthesis of a new series of vinyl complexes [Ru(CH=CHR)Cl(CO)(TBTD)(PPh3)2] (R = aryl, TBTD = 5‐(3‐thienyl)‐2,1,3‐benzothiadiazole) and shows them to be highly sensitive and selective probes for carbon monoxide in both solution and air. Depending on the vinyl substituent, chromogenic and fluorogenic responses signalled the presence of this invisible, odourless, tasteless and toxic gas. Adsorbing the complexes on silica produced colorimetric probes for the ‘naked eye’ detection of CO in the gas phase with a limit of detection as low as 8 ppm in some cases, while the release of the TBTD fluorophore allowed detection at much lower concentrations through the fluorescence response. Structural data were obtained by single crystal X‐ray diffraction techniques, while the photophysical behaviour was explored computationally using TD‐DFT experiments. The systems were also shown to be selective for CO over all other gases tested, including water vapour and common organic solvents. By introducing a poly(ethylene)glycol chain to the vinyl functionality, water compatibility was achieved and these non‐cytotoxic complexes were employed in the sensing of CO in HeLa cells, offering a simple and rapid system for sensing this gasotransmitter in this challenging medium.
Issue Date: 6-Feb-2019
Date of Acceptance: 1-Nov-2018
URI: http://hdl.handle.net/10044/1/64621
DOI: https://doi.org/10.1002/chem.201805244
ISSN: 0947-6539
Publisher: Wiley
Start Page: 2069
End Page: 2081
Journal / Book Title: Chemistry - A European Journal
Volume: 25
Issue: 8
Copyright Statement: © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: Toscani, A. , Marín-Hernández, C. , Robson, J. , Chua, E. , Dingwall, P. , White, A. , Sancenón, F. , de la Torre, C. , Martínez-Máñez, R. and Wilton-Ely, J. (2018), Highly sensitive and selective molecular probes for chromo‐fluorogenic sensing of carbon monoxide in air, aqueous solution and cells. Chem. Eur. J.. Accepted Author Manuscript., which has been published in final form at https://dx.doi.org/10.1002/chem.201805244
Sponsor/Funder: The Leverhulme Trust
Funder's Grant Number: RPG-2012-634
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
alkenyl
carbon monoxide
osmium complexes
ruthenium complexes
sensing
TRANSITION-METAL-COMPLEXES
LIVING CELLS
FLUORESCENT-PROBE
HOMOGENEOUS CATALYSIS
IMAGING APPLICATIONS
ON CHEMOSENSOR
CO DETECTION
X-RAY
WATER
COORDINATION
alkenyl
carbon monoxide
osmium complexes
ruthenium complexes
sensing
03 Chemical Sciences
General Chemistry
Publication Status: Published
Embargo Date: 2019-11-23
Online Publication Date: 2018-11-23
Appears in Collections:Chemistry
Catalysis and Advanced Materials
Faculty of Natural Sciences



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