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Diabetes mellitus and the risk of abdominal aortic aneurysm: A systematic review and meta-analysis of prospective studies

Title: Diabetes mellitus and the risk of abdominal aortic aneurysm: A systematic review and meta-analysis of prospective studies
Authors: Aune, D
Schlesinger, S
Norat, T
Riboli, E
Item Type: Journal Article
Abstract: BACKGROUND: Diabetes mellitus has been associated with reduced risk of abdominal aortic aneurysm in a number of epidemiological studies, however, until recently little data from prospective studies have been available. We therefore conducted a systematic review and meta-analysis of prospective studies to quantify the association. MATERIAL AND METHODS: Two investigators searched the PubMed and Embase databases for studies of diabetes and abdominal aortic aneurysm up to May 8th 2018. Prospective studies were included if they reported adjusted relative risk (RR) estimates and 95% confidence intervals (95% CIs) of abdominal aortic aneurysm associated with a diabetes diagnosis. Summary relative risks were estimated by use of a random effects model. RESULTS: We identified 16 prospective studies with 16,572 cases among 4,563,415 participants that could be included in the meta-analysis. The summary RR for individuals with diabetes compared to individuals without diabetes was 0.58 (95% CI: 0.51-0.66, I2 = 40.4%, pheterogeneity = 0.06). The results persisted when stratified by sex, duration of follow-up, and in most of the other subgroup analyses. There was no evidence of publication bias with Egger's test, p = 0.64 or by inspection of the funnel plots. CONCLUSIONS: These results suggest that individuals with diabetes mellitus are at a reduced risk of abdominal aortic aneurysm, however, whether pharmacological agents for diabetes mellitus explain this observation needs to be clarified in future studies.
Issue Date: 1-Dec-2018
Date of Acceptance: 9-Sep-2018
URI: http://hdl.handle.net/10044/1/64594
DOI: https://dx.doi.org/10.1016/j.jdiacomp.2018.09.009
ISSN: 1056-8727
Publisher: Elsevier
Start Page: 1169
End Page: 1174
Journal / Book Title: Journal of Diabetes and its Complications
Volume: 32
Copyright Statement: © 2018 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: World Cancer Research Fund International
Funder's Grant Number: Nil
Keywords: Abdominal aortic aneurysm
Diabetes mellitus
Meta-analysis
Prospective studies
Systematic review
1103 Clinical Sciences
Endocrinology & Metabolism
Publication Status: Published
Conference Place: United States
Online Publication Date: 2018-09-15
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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