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The impact of air pollution on our epigenome: how far is the evidence? (A systematic review)

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Title: The impact of air pollution on our epigenome: how far is the evidence? (A systematic review)
Authors: Alfano, R
Herceg, Z
Nawrot, TS
Chadeau-Hyam, M
Ghantous, A
Plusquin, M
Item Type: Journal Article
Abstract: Purpose of Review This systematic review evaluated existing evidence linking air pollution exposure in humans to major epigenetic mechanisms: DNA methylation, microRNAs, long noncoding RNAs, and chromatin regulation. Recent Findings Eighty-two manuscripts were eligible, most of which were observational (85%), conducted in adults (66%) and based on DNA methylation (79%). Summary Most observational studies, except panel, demonstrated modest effects of air pollution on the methylome. Panel and experimental studies revealed a relatively large number of significant methylome alterations, though based on smaller sample sizes. Particulate matter levels were positively associated in several studies with global or LINE-1 hypomethylation, a hallmark of several diseases, and with decondensed chromatin structure. Several air pollution species altered the DNA methylation clock, inducing accelerated biological aging. The causal nature of identified associations is not clear, however, especially that most originate from countries with low air pollution levels. Existing evidence, gaps, and perspectives are highlighted herein.
Issue Date: 1-Dec-2018
Date of Acceptance: 20-Sep-2018
URI: http://hdl.handle.net/10044/1/64128
DOI: https://dx.doi.org/10.1007/s40572-018-0218-8
ISSN: 2196-5412
Publisher: Springer (part of Springer Nature)
Start Page: 544
End Page: 578
Journal / Book Title: Current Environmental Health Reports
Volume: 5
Issue: 4
Copyright Statement: © 2018 Springer Nature Switzerland AG. The final publication is available at Springer via https://dx.doi.org/10.1007/s40572-018-0218-8
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 308610
Keywords: Air pollution
Chromatin
DNA methylation
Epigenetics
MicroRNAs
Noncoding RNA
Publication Status: Published
Embargo Date: 2019-10-25
Online Publication Date: 2018-10-25
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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