A beta(42)/A beta(40) and A beta(42)/A beta(38 ) ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer's disease: a pilot study

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Title: A beta(42)/A beta(40) and A beta(42)/A beta(38 ) ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer's disease: a pilot study
Authors: Koychev, I
Galna, B
Zetterberg, H
Lawson, J
Zamboni, G
Ridha, BH
Rowe, JB
Thomas, A
Howard, R
Malhotra, P
Ritchie, C
Lovestone, S
Rochester, L
Item Type: Journal Article
Abstract: Gait disturbances are some of the earliest changes in dementia and their monitoring presents an opportunity for early diagnosis. The exact relationship between gait and well-established biomarkers of Alzheimer’s disease (AD) remains to be clarified. In this study we compared gait-related measures with cerebrospinal fluid (CSF) markers of AD pathology. We recruited seventeen participants with mild AD in a multi-site study and performed gait assessment as well as lumbar punctures to obtain CSF. CSF Aβ42/Aβ40 and Aβ42/Aβ38 correlated positively with measures of variability (step time and step length) in the clinic-based assessments. This was driven by a negative relationship between gait variability and Aβ40 and Aβ38 but not Aβ42.The amyloid ratios and gait variability measures were also associated with more severe functional impairment. We interpret these data as an indication that increasing amyloid production (i.e., increasing Aβ40 and Aβ38) is associated with diminishing cognitive-motor control of gait. These preliminary results suggest that the two amyloid ratios may be a marker of the earliest disturbances in the interplay between cognitive and motor control which characterize dementia.
Issue Date: 25-Sep-2018
Date of Acceptance: 1-Aug-2018
URI: http://hdl.handle.net/10044/1/64095
DOI: https://dx.doi.org/10.3233/JAD-180622
ISSN: 1387-2877
Publisher: IOS Press
Start Page: 1377
End Page: 1383
Journal / Book Title: Journal of Alzheimer's Disease
Volume: 65
Issue: 4
Copyright Statement: © 2018 IOS Press and the authors. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY- NC 4.0 - https://creativecommons.org/licenses/by-nc/4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Alzheimer's disease
amyloid
biomarkers
cerebrospinal fluid proteins
gait
COGNITIVE IMPAIRMENT
CEREBROSPINAL-FLUID
OLDER-ADULTS
PARKINSONS-DISEASE
DUAL-TASK
DEMENTIA
BRAIN
VALIDATION
SCALE
MOTOR
Alzheimer’s disease
amyloid
biomarkers
cerebrospinal fluid proteins
gait
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Alzheimer's disease
amyloid
biomarkers
cerebrospinal fluid proteins
gait
COGNITIVE IMPAIRMENT
CEREBROSPINAL-FLUID
OLDER-ADULTS
PARKINSONS-DISEASE
DUAL-TASK
DEMENTIA
BRAIN
VALIDATION
SCALE
MOTOR
1103 Clinical Sciences
1702 Cognitive Science
1109 Neurosciences
Neurology & Neurosurgery
Publication Status: Published
Online Publication Date: 2018-09-25
Appears in Collections:Department of Medicine
Faculty of Medicine



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