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Human Early Life Exposome (HELIX) study: a European population-based exposome cohort

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Title: Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
Authors: Maitre, L
De Bont, J
Casas, M
Robinson, O
Aasvang, GM
Agier, L
Andrušaitytė, S
Ballester, F
Basagaña, X
Borràs, E
Brochot, C
Bustamante, M
Carracedo, A
De Castro, M
Dedele, A
Donaire-Gonzalez, D
Estivill, X
Evandt, J
Fossati, S
Giorgis-Allemand, L
R Gonzalez, J
Granum, B
Grazuleviciene, R
Bjerve Gützkow, K
Småstuen Haug, L
Hernandez-Ferrer, C
Heude, B
Ibarluzea, J
Julvez, J
Karachaliou, M
Keun, HC
Hjertager Krog, N
Lau, C-HE
Leventakou, V
Lyon-Caen, S
Manzano, C
Mason, D
McEachan, R
Meltzer, HM
Petraviciene, I
Quentin, J
Roumeliotaki, T
Sabido, E
Saulnier, P-J
Siskos, AP
Siroux, V
Sunyer, J
Tamayo, I
Urquiza, J
Vafeiadi, M
Van Gent, D
Vives-Usano, M
Waiblinger, D
Warembourg, C
Chatzi, L
Coen, M
Van den Hazel, P
Nieuwenhuijsen, MJ
Slama, R
Thomsen, C
Wright, J
Vrijheid, M
Item Type: Journal Article
Abstract: Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31 472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6–11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6–11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. Future plans HELIX study results will inform on the early life exposome and its association with molecular omics signatures and child health outcomes. Cohort data are accessible for future research involving researchers external to the project.
Issue Date: 10-Sep-2018
Date of Acceptance: 28-Aug-2018
URI: http://hdl.handle.net/10044/1/64064
DOI: https://dx.doi.org/10.1136/bmjopen-2017-021311
ISSN: 2044-6055
Publisher: BMJ Journals
Journal / Book Title: BMJ Open
Volume: 8
Copyright Statement: © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 308333
Keywords: birth cohort
community child health
epidemiology
exposome
omics
public health
Publication Status: Published
Article Number: e021311
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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