Covalently attached antimicrobial surfaces using BODIPY: improving efficiency and effectiveness

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Title: Covalently attached antimicrobial surfaces using BODIPY: improving efficiency and effectiveness
Authors: Peveler, WJ
Noimark, S
Al-Azawi, H
Hwang, GB
Crick, CR
Allan, E
Edel, JB
Ivanov, AP
MacRobert, AJ
Parkin, IP
Item Type: Journal Article
Abstract: The development of photoactivated antimicrobial surfaces that kill pathogens through the production of singlet oxygen has proved very effective in recent years, with applications in medical devices and hospital touch surfaces, to improve patient safety and well being. However, many of these surfaces require a swell-encapsulation-shrink strategy to incorporate the photoactive agents in a polymer matrix, and this is resource intensive, given that only the surface fraction of the agent is active against bacteria. Furthermore, there is a risk that the agent will leach from the polymer and thus raises issues of biocompatibility and patient safety. Here, we describe a more efficient method of fabricating a silicone material with a covalently attached monolayer of photoactivating agent that uses heavy-atom triplet sensitization for improved singlet oxygen generation and corresponding antimicrobial activity. We use boron-dipyrromethane with a reactive end group and incorporated Br atoms, covalently attached to poly(dimethylsiloxane). We demonstrate the efficacy of this material in producing singlet oxygen and killing Staphylococcus aureus and suggest how it might be easily modifiable for future antimicrobial surface development.
Issue Date: 10-Jan-2018
Date of Acceptance: 6-Dec-2017
URI: http://hdl.handle.net/10044/1/63991
DOI: https://dx.doi.org/10.1021/acsami.7b13273
ISSN: 1944-8244
Publisher: American Chemical Society
Start Page: 98
End Page: 104
Journal / Book Title: ACS Applied Materials and Interfaces
Volume: 10
Issue: 1
Copyright Statement: © 2017 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY - https://creativecommons.org/licenses/by/4.0/) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Keywords: Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
BODIPY
antimicrobial
PDMS
singlet oxygen
fluorescence microscopy
CARE-ASSOCIATED INFECTIONS
SINGLET OXYGEN GENERATION
PHOTODYNAMIC THERAPY
ANTIBACTERIAL ACTIVITY
STAPHYLOCOCCUS-AUREUS
METHYLENE-BLUE
PHOTOSENSITIZER
LIGHT
SILICONE
DYES
BODIPY
PDMS
antimicrobial
fluorescence microscopy
singlet oxygen
Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
BODIPY
antimicrobial
PDMS
singlet oxygen
fluorescence microscopy
CARE-ASSOCIATED INFECTIONS
SINGLET OXYGEN GENERATION
PHOTODYNAMIC THERAPY
ANTIBACTERIAL ACTIVITY
STAPHYLOCOCCUS-AUREUS
METHYLENE-BLUE
PHOTOSENSITIZER
LIGHT
SILICONE
DYES
0904 Chemical Engineering
0303 Macromolecular And Materials Chemistry
0306 Physical Chemistry (Incl. Structural)
Nanoscience & Nanotechnology
Publication Status: Published
Online Publication Date: 2017-12-06
Appears in Collections:Chemistry
Faculty of Natural Sciences



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