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Cellular senescence: The sought or the unwanted?

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Title: Cellular senescence: The sought or the unwanted?
Authors: Sun, Y
Coppé, J-P
Lam, EW
Item Type: Journal Article
Abstract: Cellular senescence is a process that results in irreversible cell-cycle arrest, and is thought to be an autonomous tumor-suppressor mechanism. During senescence, cells develop distinctive metabolic and signaling features, together referred to as the senescence-associated secretory phenotype (SASP). The SASP is implicated in several aging-related pathologies, including various malignancies. Accumulating evidence argues that cellular senescence acts as a double-edged sword in human cancer, and new agents and innovative strategies to tackle senescent cells are in development pipelines to counter the adverse effects of cellular senescence in the clinic. We focus on recent discoveries in senescence research and SASP biology, and highlight the potential of SASP suppression and senescent cell clearance in advancing precision medicine.
Issue Date: 1-Oct-2018
Date of Acceptance: 25-Aug-2018
URI: http://hdl.handle.net/10044/1/63920
DOI: https://dx.doi.org/10.1016/j.molmed.2018.08.002
ISSN: 1471-4914
Publisher: Elsevier (Cell Press)
Start Page: 871
End Page: 885
Journal / Book Title: Trends in Molecular Medicine
Volume: 24
Issue: 10
Copyright Statement: © 2018 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Cancer Research UK
Breast Cancer Now
Medical Research Council (MRC)
Funder's Grant Number: C37/A12011
2012MayPR070
MR/N012097/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
Medicine, Research & Experimental
Research & Experimental Medicine
INFLAMMATORY CYTOKINE SECRETION
ONCOGENE-INDUCED SENESCENCE
CYCLIC GMP-AMP
TUMOR MICROENVIRONMENT
PARACRINE SENESCENCE
THERAPY RESISTANCE
CANCER DEVELOPMENT
GENE-EXPRESSION
CYTOSOLIC DNA
LIVER-CANCER
aging-related pathology
cancer
cellular senescence
senescence-associated secretory phenotype
senolytics
therapy-induced senescence
06 Biological Sciences
11 Medical And Health Sciences
Immunology
Publication Status: Published
Embargo Date: 2019-08-25
Online Publication Date: 2018-08-25
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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