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Single Particle Automated Raman Trapping Analysis

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Title: Single Particle Automated Raman Trapping Analysis
Authors: Penders, J
Pence, I
Horgan, C
Bergholt, M
Wood, C
Najer, A
Kauscher, U
Nagelkerke, A
Stevens, MM
Item Type: Journal Article
Abstract: Enabling concurrent, high throughput analysis of single nanoparticles would greatly increase the capacity to study size, composition and inter and intra particle population variance with applications in a wide range of fields from polymer science to drug delivery. Here, we present a comprehensive platform for Single Particle Automated Raman Trapping Analysis (SPARTA) able to integrally analyse nanoparticles ranging from synthetic polymer particles to liposomes without any modification. With the developed highly controlled automated trapping process, single nanoparticles are analysed with high throughput and sensitivity to resolve particle mixtures, obtain detailed compositional spectra of complex particles, track sequential functionalisations, derive particle sizes and monitor the dynamics of click reactions occurring on the nanoparticle surface. The SPARTA platform opens up a wide range of new avenues for nanoparticle research through label-free integral high-throughput single particle analysis, overcoming key limitations in sensitivity and specificity of existing bulk analysis methods.
Issue Date: 15-Oct-2018
Date of Acceptance: 28-Aug-2018
URI: http://hdl.handle.net/10044/1/63918
DOI: https://dx.doi.org/10.1038/s41467-018-06397-6
ISSN: 2041-1723
Publisher: Nature Publishing Group
Journal / Book Title: Nature Communications
Volume: 9
Copyright Statement: © 2018 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Sponsor/Funder: Engineering & Physical Science Research Council (E
Wellcome Trust
Commission of the European Communities
Commission of the European Communities
Funder's Grant Number: EP/K031953/1
098411/Z/12/Z
676137
701713
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
NANOPARTICLE TRACKING ANALYSIS
PHOSPHOLIPID-VESICLES
POLYMER VESICLES
MICROSCOPY
SPECTROSCOPY
MEMBRANES
TWEEZERS
MD Multidisciplinary
Publication Status: Published
Article Number: 4256
Appears in Collections:Faculty of Engineering
Materials
Faculty of Natural Sciences



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