Altmetric

The role of biophysics and engineering in investigating tumour pH and its regulation

File Description SizeFormat 
Revised Sikka manuscript for Special Issue-Precision Medicine 2016 accepted.docxAccepted version219.79 kBMicrosoft WordView/Open
Title: The role of biophysics and engineering in investigating tumour pH and its regulation
Authors: Sikka, A
Barnes, EME
Keun, HC
Item Type: Journal Article
Abstract: Solid tumours tend to have a high metabolic rate, inducing the intracellular accumulation of lactic acid and CO2 with a concomitant decrease in pH. Since many intracellular processes are pH-sensitive, tumour progression is therefore dependent on the maintenance of intracellular and extracellular pH within a narrow range. Cancer cells employ a number of functionally redundant regulatory mechanisms to maintain pH homeostasis. Several small molecule inhibitors which target these mechanisms are currently in clinical trials with promising outcomes. In order to investigate tumour pH regulation and to stratify and monitor patient response to these treatments, we need to be able to accurately measure pH in situ. Although pH measurement techniques are continually being developed, they are still limited for example by poor probe targeting and spatio-temporal resolution. In this review, we discuss the important role of biophysics and engineering in tackling the challenges faced when measuring tumour pH.
Issue Date: 1-Mar-2017
Date of Acceptance: 30-Jan-2017
URI: http://hdl.handle.net/10044/1/63855
DOI: https://dx.doi.org/10.1088/2057-1739/aa5cd9
ISSN: 2057-1739
Publisher: IOP Publishing
Journal / Book Title: Convergent Science Physical Oncology
Volume: 3
Issue: 1
Copyright Statement: © 2018 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article accepted for publication in Convergent Science Physical Oncology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at https://dx.doi.org/10.1088/2057-1739/aa5cd9.
Sponsor/Funder: Cancer Research UK
Funder's Grant Number: A19482
Keywords: cancer
pH
biophysics
engineering
CARBONIC-ANHYDRASE IX
INTRACELLULAR PH
CANCER-CELLS
OPTICAL NANOSENSORS
QUANTUM DOTS
LIVING CELLS
ACIDIC PH
METABOLISM
NANOPARTICLES
HYPOXIA
Publication Status: Published
Article Number: 013003
Online Publication Date: 2017-02-23
Appears in Collections:Division of Surgery
Division of Cancer



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx