Embedded Phase-Amplitude Coupling Based Closed-Loop Platform for Parkinson's Disease

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Title: Embedded Phase-Amplitude Coupling Based Closed-Loop Platform for Parkinson's Disease
Authors: Moly, A
Luan, S
Zoltan, M
Salimpour, Y
Anderson, W
Constandinou, TG
Grand, L
Item Type: Conference Paper
Abstract: Deep Brain Stimulation (DBS) is a widely used clin- ical therapeutic modality to treat Parkinsons disease refractory symptoms and complications of levodopa therapy. Currently available DBS systems use continuous, open-loop stimulation strategies. It might be redundant and we could extend the battery life otherwise. Recently, robust electrophysiological signatures of Parkinsons disease have been characterized in motor cortex of patients undergoing DBS surgery. Reductions in the beta- gamma Phase-Amplitude coupling (PAC) correlated with symp- tom improvement, and the therapeutic effects of DBS itself. We aim to develop a miniature, implantable and adaptive system, which only stimulates the neural target, when triggered by the output of the appropriate PAC algorithm. As a first step, in this paper we compare published PAC algorithms by using human data intra-operatively recorded from Parkinsonian patients. We then introduce IIR masking for later achieving fast and low- power FPGA implementation of PAC mapping for intra-operative studies. Our closed-loop application is expected to consume significantly less power than current DBS systems, therefore we can increase the battery life, without compromising clinical benefits.
Issue Date: 17-Oct-2018
Date of Acceptance: 13-Aug-2018
URI: http://hdl.handle.net/10044/1/63455
Publisher: IEEE
Start Page: 1
End Page: 4
Copyright Statement: This paper is embargoed until publication.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/M020975/1
Conference Name: IEEE Biomedical Circuits and Systems (BioCAS) Conference
Publication Status: Accepted
Start Date: 2018-10-17
Finish Date: 2018-10-19
Conference Place: Cleveland, Ohio, USA
Embargo Date: publication subject to indefinite embargo
Appears in Collections:Faculty of Engineering
Electrical and Electronic Engineering

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