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The CELEB trial: Comparative effectiveness of lung volume reduction surgery for emphysema and bronchoscopic lung volume reduction with valve placement. A protocol for a randomised controlled trial

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Title: The CELEB trial: Comparative effectiveness of lung volume reduction surgery for emphysema and bronchoscopic lung volume reduction with valve placement. A protocol for a randomised controlled trial
Authors: Buttery, S
Kemp, S
Shah, P
Waller, D
Jordan, S
Lee, JL
Banya, W
Steiner, M
Hopkinson, N
Item Type: Journal Article
Abstract: Introduction: Although lung volume reduction surgery and bronchoscopic lung volume reduction with endobronchial valves have both been shown to improve lung function, exercise capacity and quality of life in appropriately selected patients with emphysema, there are no direct comparison data between the two procedures to inform clinical decision making. Methods and Analysis: We describe the protocol of the CELEB study (ISRCTN19684749), a randomised controlled trial which will compare outcomes at 1 year between the two procedures, using a composite disease severity measure, the iBODE score, which includes body mass index, lung function, breathlessness and exercise capacity. Ethics and Dissemination: Ethical approval to conduct the study has been obtained from the Fulham Research Ethics Committee, London (16/LO/0286). The outcome of this trial will provide information to guide treatment choices in this population and will be presented at national and international meetings and published in peer-reviewed journals. We will also disseminate the main results to all participants in a letter.
Issue Date: 17-Oct-2018
Date of Acceptance: 7-Aug-2018
URI: http://hdl.handle.net/10044/1/63322
DOI: https://dx.doi.org/10.1136/bmjopen-2017-021368
ISSN: 2044-6055
Publisher: BMJ Journals
Journal / Book Title: BMJ Open
Volume: 8
Copyright Statement: © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
Sponsor/Funder: National Institute for Health Research
National Institute for Health Research
British Lung Foundation
Funder's Grant Number: PB-PG-1014-35051
UD99999959
BLF-PLMNX15-1
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
ENDOBRONCHIAL VALVES
HETEROGENEOUS EMPHYSEMA
PHYSICAL-ACTIVITY
COPD
EXERCISE
OUTCOMES
COPD
emphysema
lung volume reduction
thoracic surgery
Publication Status: Published
Article Number: ARTN e021368
Online Publication Date: 2018-10-17
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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